CD30 in Lymphoma: An Increasingly Important Role in Testing and Targeting

Release Date: January 3, 2017
Last Reviewed: December 22, 2016
Expiration Date: January 3, 2018
Time to Complete Activity: 1.0 hour

*This activity expired for credit on January 3, 2018 and is no longer available for credit
This activity is provided by Global Education Group. Paradigm Medical Communications, LLC is the educational partner.
Steven M. Horwitz, MD
Associate Attending Physician
Department of Medicine
Memorial Sloan Kettering Cancer Center
New York, NY

Ratesh Khillan, MD
Interfaith Medical Center
Brooklyn, NY
Steering Committee
Steven T. Rosen, MD (Chair)
Provost and Chief Scientific Officer
Director, Comprehensive Cancer Center and Beckman Research Institute
Irell & Manella Cancer Center Director’s Distinguished Chair
City of Hope
Duarte, CA
Keri A. Halsema, NP
Nurse Practitioner
Hematology-Oncology/Bone Marrow Transplant Department
University of Colorado Hospital
Aurora, CO
Steven M. Horwitz, MD
Associate Attending Physician
Department of Medicine
Memorial Sloan Kettering Cancer Center
New York, NY
Eric D. Hsi, MD
Professor of Pathology
Cleveland Clinic Lerner College of Medicine
Section Head, Hematopathology
Chair, Department of Laboratory Medicine
Robert J. Tomsich Pathology and Laboratory Medicine Institute
Cleveland Clinic
Cleveland, OH
Target Audience
This activity has been designed to address the educational needs of physicians, PAs, and nurse practitioners within the specialties of oncology, hematology, hematology/oncology, and pathology. This activity will also be of benefit to other healthcare providers interested in the management of patients with CD30-positive lymphomas, including pharmacists and oncology nurses.
Learning Objectives
Upon proper completion of this activity, participants should be better able to:
  • Review the role of CD30 testing in the diagnosis of each of the subtypes of CD30-positive lymphomas.
  • Describe the role of the pathologist in diagnosing CD30-positive lymphomas and the tests used in CD30 determination.
  • Explain the utility of CD30-targeted antibody drug conjugates in treating CD30-positive lymphomas based on the mechanism of action, efficacy, toxicities, and late-phase clinical trial results.
Physician Accreditation Statement
Global Education Group is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
This CME/CE activity complies with all requirements of the federal Physician Payment Sunshine Act. If a reportable event is associated with this activity, the accredited provider managing the program will provide the appropriate physician data to the Open Payments database.
Physician Credit Designation Statement
Global Education Group designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Nurse Practitioner Continuing Education
Global Education Group is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 110121. This activity is accredited for 1.0 contact hour(s) which includes 0.3 hour(s) of pharmacology.
Activity ID #2137E.
This activity was planned in accordance with AANP CE Standards and Policies.
PA Continuing Education
AAPA accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society. PAs may receive a maximum of 1.0 Category 1 credits for completing this activity.
For information about the accreditation of this program, please contact Global at (303) 395-1782 or
Disclosure of Commercial Support
This activity is supported by an educational grant from Seattle Genetics, Inc.
Instructions for Participation
To receive a CE certificate of participation, participants must:
  • Follow instructions to register or log in with your professional information and complete the pretest.
  • View the online activity in its entirety.
  • Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest.
  • A certificate of participation will be available for download/printing immediately following your successful completion of the posttest and evaluation.
For questions regarding CE credit, contact the Paradigm CME Department at (845) 398-5949.

There is no fee required for participation in this activity.
Hardware/Software Requirements
This certified CE activity is designed using HTML5 video and audio.

Supported Browsers:
For Desktops (Windows/Mac)
Internet Explorer 9 or higher, Firefox 28 or higher, Safari 5.1 or higher, Google Chrome 31 or higher, Opera 21 or higher

For Tablets (iPad/Android/Surface)
iOS Safari 4 or higher, Android 2.3 or higher, IE Mobile 10 or higher

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Disclosure and Resolution of Conflict of Interest
Global Education Group (Global) and Paradigm Medical Communications, LLC (Paradigm) requires instructors, planners, managers, and other individuals and their spouse/life partner who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Global and Paradigm for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.
The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CE activity:
 Name of Faculty or Presenter
 Reported Financial Relationship
 Steven T. Rosen, MD (Chair)
   No financial relationships to disclose
 Keri A. Halsema, NP 
   No financial relationships to disclose
 Steven M. Horwitz, MD
Grant/Research Support: Celgene Corporation; Infinity Pharmaceuticals; Kyowa Hakko Kirin Co., Ltd; Millennium Pharmaceuticals, Inc; Seattle Genetics, Inc; Spectrum Pharmaceuticals, Inc
Retained Consultant: Amgen Inc; Bristol-Myers Squibb Company; Celgene Corporation; Millennium Pharmaceuticals, Inc; Seattle Genetics, Inc; Spectrum Pharmaceuticals, Inc
Honoraria: Amgen Inc; Bristol-Myers Squibb Company; Celgene Corporation; Millennium Pharmaceuticals, Inc; Seattle Genetics, Inc; Spectrum Pharmaceuticals, Inc
   Other (Travel): ADC Therapeutics
 Eric D. Hsi, MD
Research Support: AbbVie Inc.; Cellerant Therapeutics, Inc.; Eli Lilly and Company
   Advisory Board: Celgene Corporation; HTG Molecular Diagnostics, Inc.
   Honoraria: Seattle Genetics, Inc
 Ratesh Killan, MD
  No financial relationships to disclose
The planners and managers reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CE activity:
 Name of Planner or Manager
 Reported Financial Relationship
 Amanda Glazer, PhD
  No financial relationships to disclose
 Kristen Delisi
  No financial relationships to disclose
 Laura Gilsdorf
  No financial relationships to disclose
Paradigm Medical Communications, LLC staff members have no financial relationships to disclose.
Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global and Paradigm do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
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