Biostimulatory Fillers in Aesthetic Medicine: Keeping Ahead of the Curve
Release Date: April 9, 2019
Last Reviewed: April 7, 2019
Expiration Date: April 9, 2020
Time to Complete Activity: 0.75 hours

*This activity expired for credit on April 9, 2020 and is no longer available for credit

Sabrina G. Fabi, MD, FAAD, FAACS
Volunteer Assistant Clinical Professor
Department of Medicine/Dermatology
University of California, San Diego
Goldman Butterwick Fitzpatrick Groff and Fabi Cosmetic Laser Dermatology
San Diego, CA
Z. Paul Lorenc, MD, FACS
Medical Director
Lorenc Aesthetic Plastic Surgery Center
Department of Plastic Surgery
Lenox Hill Hospital
New York, NY
This activity is provided by Paradigm Medical Communications, LLC.  
Statement of Need
Due to rapid, ongoing progress, clinicians in aesthetic medicine are challenged to keep ahead of the curve with evolving techniques and an ever-increasing array of available products for aesthetic rejuvenation and remodeling. To conduct appropriate patient assessments and create individualized treatment plans that offer optimal results, these clinicians also need a thorough understanding of the effects of aging in the skin and deeper tissues as they relate to aesthetic rejuvenation and remodeling throughout the body. This activity will provide participants with a review of the anatomy and pathophysiology of aging; nuances of patient assessment; mechanisms of action, efficacy, and safety of injectable biostimulatory soft tissue fillers and hyaluronic acid fillers; strategies for individualizing treatment based on anatomic assessment, patient goals, and agent characteristics; and advanced techniques for selecting appropriate combinations of agents for optimal aesthetic body rejuvenation and remodeling.
Target Audience
This activity has been designed to meet the educational needs of dermatologists, plastic surgeons, facial plastic surgeons, ocular plastic surgeons, and ophthalmologists. It may also be of benefit to other physicians, nurses, and healthcare providers who are involved in the field of aesthetic medicine.
Learning Objectives
Upon proper completion of this activity, participants should be better able to:
  • Describe the pathophysiology of aging and its effects in the skin and deeper tissues as they relate to aesthetic body remodeling.
  • Discuss recent clinical data and expert insights on biostimulatory soft tissue fillers for aesthetic body remodeling, especially characteristics that affect treatment outcomes.
  • Incorporate biostimulatory soft tissue fillers into individualized treatment plans for aesthetic body remodeling when appropriate.
Physician Accreditation Statement
Paradigm Medical Communications, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Physician Credit Designation Statement
Paradigm Medical Communications, LLC designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
PA Continuing Education
PAs may claim a maximum of 0.75 Category 1 credits for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society. 
Nurse Practitioner Continuing Education
The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.

Disclosure of Commercial Support
This activity is supported by an educational grant from Galderma Laboratories, L.P.
This activity is supported with in-kind contributions: Galderma Laboratories, L.P. - disposable supplies (injectable fillers)  
Instructions for Participation
To receive a CME certificate of participation, you should:
  • Follow instructions to register or log in with your professional information and complete the pre-activity assessment
  • View the online activity in its entirety.
  • Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest.
A certificate of participation will be available for download/printing immediately following your successful completion of the posttest and evaluation.
For questions regarding CME credit, contact the Paradigm CME Department at (845) 398-5949.
There is no fee required for participation in this activity.

Hardware/Software Requirements
This certified CME activity is designed using HTML5 video. As you navigate the video using the supplied controls, the slides will sync to the speaker.
Supported Browsers
For Desktops (Windows/Mac)
Internet Explorer 9 or higher, Firefox 28 or higher, Safari 8 or higher, Google Chrome 31 or higher, Opera 21 or higher
For Tablets (iPad/Android/Surface)
iOS Safari 4 or higher, Android 2.3 or higher, IE Mobile 10 or higher
Technical Support: If you have any technical problems or playback issues email us at
In accordance with Accreditation Council for Continuing Medical Education requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in the activity. These relationships are described below.
Sabrina G. Fabi, MD, FAAD, FAACS
Consultant: Alastin Skincare, Inc; Allergan, Inc.; Colorscience, Inc.; Endo Pharmaceuticals Inc.; EVOLUS; Galderma Laboratories, L.P.; Merz North America, Inc.; Revance Therapeutics, Inc; ThermiGen, LLC; Valeant Pharmaceuticals International, Inc
Speakers’ Bureau: Alastin Skincare, Inc; Allergan, Inc.; EVOLUS; Galderma Laboratories, L.P.; Merz North America, Inc.; ThermiGen, LLC; Valeant Pharmaceuticals International, Inc
Grant/Research Support: Alastin Skincare, Inc; Allergan, Inc.; Ampersand Aesthetics; Bayer HealthCare; Colorscience, Inc.; Endo Pharmaceuticals Inc.; Galderma Laboratories, L.P.; Merz North America, Inc.; Revance Therapeutics, Inc
Stockholder: Allergan, Inc.; Revance Therapeutics, Inc
Z. Paul Lorenc, MD, FACS            
Consultant: Allergan, Inc.; Galderma Laboratories, L.P.; Johnson & Johnson Services, Inc; Merz North America, Inc.; Serene Medical; Sinclair Pharma; Suneva Medical, Inc; ThermiGen, LLC
Paradigm Medical Communications, LLC staff members have no financial relationships to disclose.
Independent peer reviewer has no financial relationships to disclose.
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This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA.
This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. Reasonable efforts have been taken to present educational subject matter in a balanced, unbiased fashion, and in compliance with regulatory requirements. However, each activity participant must always use his or her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.
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As an ACCME-accredited provider, Paradigm Medical Communications, LLC activities must include a balanced view of therapeutic options. Use of generic names contributes to this impartiality. In this activity, the trade names for aesthetic products are used for clarity. The use of trade names should not be viewed as an endorsement of specific products by Paradigm Medical Communications, LLC.
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