Harnessing Immuno-Oncology for the Management of Genitourinary Cancers: How to Optimize Checkpoint Inhibitor Therapy Based on Pathways, Patterns of Response, and Immune-related AEs
 
Release Date: July 10, 2018
Last Reviewed: July 3, 2018
Expiration Date: July 10, 2019
Time to Complete Activity: 1.0 hour
 
Faculty
Mayer N. Fishman, MD, PhD
Senior Member, Medical Oncologist
Department of Genitourinary Oncology
Department of Immunology
Moffitt Cancer Center
Professor
Department of Oncologic Sciences
Department of Internal Medicine
University of South Florida Morsani College of Medicine
Tampa, FL
 
Sumanta Kumar Pal, MD
Associate Clinical Professor
Department of Medical Oncology & Therapeutics Research
Co-director, Kidney Cancer Program
City of Hope
Duarte, CA
 
This activity is provided by Paradigm Medical Communications, LLC.  
 
Target Audience
This activity has been designed to meet the educational needs of community medical oncologists and advanced practitioners, such as nurse practitioners, PAs, and pharmacists, treating genitourinary (GU) cancers, including renal cell carcinoma and bladder cancer. This activity may also benefit other oncology healthcare professionals involved in the management of patients with renal cell carcinoma and bladder cancer.
 
Statement of Need
To provide high-quality, evidence-based care, oncologists must be familiar with the principles of immunology as they relate to the mechanisms of action of immune checkpoint inhibitors as well as the clinical profiles of these agents (as monotherapy or combination therapy) and their roles and patterns of response in first- and subsequent-line treatment of GU cancers, including bladder cancer and renal cell carcinoma. This activity will educate clinicians how to appropriately integrate immune checkpoint inhibitors into clinical practice for treatment of patients with GU cancers.
 
Learning Objectives
Upon proper completion of this activity, participants should be better able to:
  • Describe the principles of immunology as they relate to the mechanisms of action and pathways of immune checkpoint inhibitors in the treatment of genitourinary cancers, including renal cell and bladder cancer.
  • Incorporate the latest efficacy data and clinical profiles of new and emerging immune checkpoint inhibitors into optimal management decisions, including recognition of patterns of response, in patients with genitourinary cancer, including renal cell and bladder cancer.
  • Evaluate approaches to manage immune-related adverse effects associated with immune checkpoint inhibitors in patients with genitourinary cancer, including renal cell and bladder cancer.
 
Table of Contents
  • Introduction
  • Immuno-oncology Principles in Genitourinary Cancers
  • Case 1: Newly Diagnosed Metastatic Bladder Cancer
  • Case 2: Newly Diagnosed Metastatic Renal Cell Carcinoma
  • Managing Immune-related Adverse Events
  • Conclusions
 
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Physician Credit Designation Statement
Paradigm Medical Communications, LLC, designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
 
Pharmacist Accreditation and Designation Statement
Educational Review Systems is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. This program is approved for 1.0 hours (0.10 CEUS) of continuing pharmacy education credit. Proof of participation will be posted to your NABP CPE profile within 4 to 6 weeks to participants who have successfully completed the post-test. Participants must participate in the entire presentation and complete the course evaluation to receive continuing pharmacy education credit. (Universal Activity Number 0761-9999-18-233-H01-P)
 
This is a knowledge-based activity.
 
This activity is jointly provided by Educational Review Systems, Inc., and Paradigm Medical Communications, LLC.     
                                                                                       

PA Continuing Education
PAs may claim a maximum of 1.0 Category 1 credits for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society.
 
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The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.  Individuals are responsible for checking with the AANPCP for further guidelines.
 
Disclosure of Commercial Support
This activity is supported by an educational grant from Merck & Co., Inc.
 
Instructions for Participation
To receive CE credit, you should:
  • Follow instructions to register or log in with your professional information and complete the pre-activity assessment.
  • View the online activity in its entirety.
  • Complete and submit the online posttest and evaluation.
A certificate of participation/statement of completion will be available for download/printing immediately following your successful completion of the posttest and evaluation.

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For Desktops (Windows/Mac)
Internet Explorer 9 or higher, Firefox 28 or higher, Safari 5.1 or higher, Google Chrome 31 or higher, Opera 21 or higher
 
For Tablets (iPad/Android/Surface)
iOS Safari 4 or higher, Android 2.3 or higher, IE Mobile 10 or higher
 
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Disclosures
In accordance with ACCME and ACPE requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in the activity. These relationships are described below.
 
Mayer N. Fishman, MD, PhD
Grant/Research Support: Bristol-Myers Squibb Company; Eisai, Inc; Hofffman-LaRoche; Medivation, Inc.
Retained Consultant: Exelixis, Inc
 
Sumanta Kumar Pal, MD
Retained Consultant: Astellas Pharma US, Inc; AVEO Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; Eisai, Inc; Exelixis, Inc; Genentech, Inc.; Ipsen Biopharmaceuticals, Inc.; Novartis; Pfizer Inc; Roche
 
Paradigm Medical Communications, LLC, staff members have no financial relationships to disclose.

Educational Review Systems, Inc., staff members have no financial relationships to disclose.

Independent peer reviewer has no financial relationships to disclose.

Patient reviewer, Peggy Margaret Zuckerman, has the following financial relationships to disclose:
Retained Consultant: Patient-Centered Outcomes Research Institute; Roche/Genentech, Inc
Ownership Interest: Celgene Corporation; Gilead Sciences, Inc
 
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