Management of Pemphigus Vulgaris: Challenges and Solutions
Release Date: September 14, 2018
Last Reviewed: July 18, 2018
Expiration Date: September 14, 2019
Time to Complete Activity:  1.0 hour

*This activity expired for credit on September 14, 2019 and is no longer available for credit

This activity is provided by Global Education Group. UNLV School of Dental Medicine and Paradigm Medical Communications, LLC, are the educational partners.

Victoria P. Werth, MD
Professor of Dermatology and Medicine
University of Pennsylvania and Philadelphia VAMC
Department of Dermatology
Perelman Center for Advanced Medicine
Philadelphia, PA
Jacob O. Levitt, MD
Vice Chairman, Professor
The Mount Sinai Medical Center
The Icahn School of Medicine at Mount Sinai
Department of Dermatology
New York, NY
Target Audience
This activity has been designed for dermatologic and dental clinicians. It may also benefit other healthcare providers (HCPs) interested in the management of pemphigus vulgaris, including rheumatologists and hematologists.
Statement of Need
Pemphigus vulgaris (PV) belongs to a group of rare autoimmune mucocutaneous blistering disorders that were often fatal prior to the introduction of effective treatments. There are, as yet, no US guidelines regarding the diagnosis or management of PV. In the absence of a cure, treatments focus on decreasing new blister formation and promoting healing of current blisters/erosions, without causing undue adverse effects. While dermatologists are typically the primary clinicians to diagnose and manage PV, dental clinicians are well-positioned to aid in the diagnosis of PV, since they may be the first HCPs to notice oral lesions that occur in PV. Other clinicians (such as rheumatologists) help administer some of the treatments and assist in the prevention and management of adverse treatment effects. Management has evolved from corticosteroids to steroid-sparing immunosuppressant agents, cyclophosphamide, rituximab, intravenous immunoglobulin, immunoadsorption, and plasmapheresis. Many clinicians would benefit from ongoing education that delineates evidence-based recommendations for management of PV, including how to integrate current and emerging clinical trial data into the decision-making process.
Learning Objectives
Upon proper completion of this activity, participants should be better able to:
  • Identify the process by which a clinical diagnosis of pemphigus vulgaris is made.
  • Apply findings from trials of current and emerging therapies to select treatment for patients with pemphigus vulgaris.
Physician Accreditation Statement
Global Education Group is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
This CME/CE activity complies with all requirements of the federal Physician Payment Sunshine Act. If a reportable event is associated with this activity, the accredited provider managing the program will provide the appropriate physician data to the Open Payments database.
Physician Credit Designation Statement
Global Education Group designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
For information about the accreditation of this program, please contact Global at (303) 395-1782 or
Dental Professional Continuing Education
This continuing education activity has been planned and implemented in accordance with the standards of the ADA Continuing Education Recognition Program (ADA CERP) through joint efforts between UNLV School of Dental Medicine, Global Education Group, and Paradigm Medical Communications, LLC.

UNLV School of Dental Medicine is an ADA CERP approved provider. ADA CERP is a service of the American Dental Association to assist dental professionals in identifying quality providers of continuing dental education. ADA CERP does not approve or endorse individual courses or instructors, nor does it imply acceptance of credit hours by boards of dentistry.
Concerns or complaints about a CE provider may be directed to the provider or to the Commission for Continuing Education Provider Recognition at

The UNLV School of Dental Medicine designates this activity for 1.0 continuing education credits.
This activity has been planned and implemented in accordance with the standards of the Academy of General Dentistry Program Approval for Continuing Education (PACE) through the joint program provider approval of UNLV School of Dental Medicine, Global Education Group, and Paradigm Medical Communications, LLC.
UNLV School of Dental Medicine is designated as an Approved PACE Program Provider by the Academy of General Dentistry. The formal continuing education programs of this program provider are accepted by the AGD for Fellowship/Mastership and membership maintenance credit. Approval does not imply acceptance by a state or provincial board of dentistry or AGD endorsement. Nationally Approved From 6/1/2017 - 5/31/2021. Provider ID #213111
Disclosure of Commercial Support
This activity is supported by an educational grant from Genentech, Inc.
Instructions for Participation
To receive a CE certificate of participation, participants must:
  • Follow instructions to register or log in with your professional information and complete the pretest.
  • View the online activity in its entirety.
  • Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest.
A certificate of participation/certificate of completion will be available for download/printing immediately following your successful completion of the posttest and evaluation.
For questions regarding CE credit, contact the Paradigm CME Department at (845) 398-5949.
There is no fee required for this educational activity.
Hardware/Software Requirements
This certified CME activity is designed using HTML5 video. As you navigate the video using the supplied controls, the slides will sync to the speaker.
Supported Browsers:
For Desktops (Windows/Mac)
Internet Explorer 9 or higher, Firefox 28 or higher, Safari 5.1 or higher, Google Chrome 31 or higher, Opera 21 or higher
For Tablets (iPad/Android/Surface)
iOS Safari 4 or higher, Android 2.3 or higher, IE Mobile 10 or higher
Technical Support: If you have any technical problems or playback issues email us at
Disclosure and Resolution of Conflict of Interest
Global Education Group (Global), UNLV School of Dental Medicine (UNLV), and Paradigm Medical Communications, LLC (Paradigm) require instructors, planners, managers, and other individuals and their spouse/life partner who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Global, UNLV, and Paradigm for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.
The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CE activity:
Name of Faculty or Presenter
Reported Financial Relationship
Victoria P. Werth, MD
Grant/Research Support: Genentech, Inc/Roche; Syntimmune, Inc.
Retained Consultant: Genentech, Inc/Roche; Immune Pharmaceuticals; Principia Biopharma; Syntimmune, Inc.
Jacob O. Levitt, MD
Retained Consultant: AbbVie Inc, Novartis
Honoraria: Corrona, LLC; Eli Lilly and Company; Genentech, Inc; Janssen Pharmaceuticals, Inc; Regeneron Pharmaceuticals, Inc; UCB, Inc.
The planners and managers reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CE activity:
Name of Planner or Manager
Reported Financial Relationship
Lindsay Borvansky
No financial relationships to disclose
Andrea Funk
No financial relationships to disclose
Liddy Knight
No financial relationships to disclose
Andrew Ingel, DMD, FAGD
No financial relationships to disclose
Victoria Woo, DDS
No financial relationships to disclose
Victoria Arthur
No financial relationships to disclose
Paradigm Medical Communications, LLC, staff members have no financial relationships to disclose.

Independent peer reviewer has no financial relationships to disclose.

Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global Education Group, UNLV, and Paradigm do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
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The materials provided for this activity are for informational purposes only and should not be used for diagnosis or treatment of a health problem without consulting a licensed medical professional. Any views or opinions presented are solely those of the faculty members, and do not necessarily represent those of Global Education Group, UNLV or Paradigm Medical Communications, LLC. References to any entity, product, service, or source of information on this website should not be considered an endorsement, either direct or implied, by Global, UNLV or Paradigm. Global, UNLV and Paradigm accept no liability for the content referenced in this activity.
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The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing the program. Required items include first name, last name, degree, and email address. These items are necessary. Participants are also required to complete an evaluation of the CE activity. All evaluative information submitted is collected and retained and used by Global, UNLV and Paradigm to continuously improve the learning experience.
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