Exploring Nuances Among Targeted and Immune Checkpoint Therapies in Melanoma:
Focus on Mechanisms, BRAF Mutation, and Achieving a Durable Response

Release Date: 02/3/2020 
Last Reviewed: 1/31/2020
Expiration Date: 02/3/2021
Time to Complete Activity:  1.0 hour

Faculty Presenter
Sanjiv S. Agarwala, MD

Professor of Medicine
Temple University School of Medicine
Philadelphia, PA

Steering Committee 
Sanjiv S. Agarwala, MD

Professor of Medicine
Temple University School of Medicine
Philadelphia, PA

Ragini R. Kudchadkar, MD
Associate Professor 
Department of Hematology and Medical Oncology 
Winship Cancer Institute 
Emory University School of Medicine 
Atlanta, GA
This activity is provided by Paradigm Medical Communications, LLC.

Target Audience
This activity has been designed to address the educational needs of community medical oncologists. It will also be of benefit to surgical oncologists, oncology nurses, residents, fellows, nurse practitioners (NPs), PAs, dermatologists, dermatopathologists, and other clinicians who treat patients with melanoma. 

Statement of Need
The treatment of advanced melanoma has shifted dramatically since the introduction of immune checkpoint inhibitors and BRAF/MEK inhibitors. Now, community oncology clinicians have multiple treatment options for their patients with stage III and IV disease that include both targeted and immunotherapies. However, treatment selection is highly complex, requiring consideration of multiple patient-, disease-, and treatment-related variables. It is therefore critical to provide community oncology clinicians with education about optimal treatment selection for immune checkpoint inhibitors with a discussion of how their mechanisms of action (MOA) differ from that of targeted therapies; the latest clinical trial data that provide clues to nuances between and within drug classes; selecting agents that can provide a durable response; sequencing of agents; and differences in safety profiles. Importantly, community oncology clinicians must also be adept at recognizing and effectively managing immune-related adverse events (irAEs).

Learning Objectives

Upon proper completion of this activity, participants should be better able to:
  • Review the MOA of immune checkpoint inhibitors and how they differ from those of BRAF–targeted therapies used for the treatment of advanced melanoma
  • Select optimal immunotherapy for patients with advanced melanoma, based on the latest clinical trial data, demonstrating durable response rates as well as nuanced differences between immune checkpoint inhibitors and BRAF-targeted therapies
  • Effectively manage irAEs associated with immune checkpoint inhibitors used in the treatment of advanced melanoma, according to the latest guideline-recommended strategies
  • The Evolving Landscape of Melanoma Treatment
  • Immune Checkpoint Inhibitors for Melanoma: Treatment Selection Using the Latest Clinical Trial Data
  • Effective Management of irAEs
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Disclosure of Commercial Support 
This activity is supported by an educational grant from Bristol-Myers Squibb.

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In accordance with ACCME requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in the activity. These relationships are described below.

Steering Committee 
Sanjiv S. Agarwala, MD

Retained Consultant: Bristol-Myers Squibb; Merck & Co., Inc

Ragini R. Kudchadkar, MD 
Retained Consultant: Array BioPharma Inc.; Bristol-Myers Squibb; Immunocore; Novartis Pharmaceuticals Corporation
Grant/Research Support: Bristol-Myers Squibb; Merck & Co., Inc

Paradigm Medical Communications, LLC staff members have no financial relationships to disclose.

Independent peer reviewer has no financial relationships to disclose.

Independent fellow has no financial relationships to disclose.

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