Enzymatic Therapy for Dupuytren’s Contracture: Resolving Barriers to Optimal Care

Release Date: February 15, 2021
Last Reviewed: February 1, 2021
Expiration Date: February 15, 2023
Time to Complete Activity: 1.0 hour 
*This activity expired for credit on February 15, 2023 and is no longer available for credit

Steering Committee/Faculty

Lawrence C. Hurst, MD (Chair)
Chief, Division of Hand Surgery 
Professor and Chair
Department of Orthopaedics and Rehabilitation
Stony Brook University Hospital
Stony Brook, NY

Philip Blazar, MD
Chief, Harvard Hand and Upper Extremity
Associate Professor of Orthopedic Surgery
Harvard Medical School
Boston, MA

Samantha I. Muhlrad, MD 
Orthopedic Surgeon 
Stony Brook University Hospital
Stony Brook, NY
This activity is provided by Paradigm Medical Communications, LLC.    

Disclosure of Commercial Support
This activity is supported by an educational grant from Endo Pharmaceuticals Inc.

This activity is supported with in-kind contributions: 
Endo Pharmaceuticals Inc.  ̶  disposable supplies (vials)

Target Audience
This activity has been designed to meet the educational needs of orthopedic surgeons, hand surgeons, and plastic and reconstructive surgeons. It may also be of benefit to orthopedic nurses, nurse practitioners, PAs, and other healthcare providers who manage patients with Dupuytren’s contracture. 

Statement of Need
Dupuytren’s disease (DD) is a benign, generally painless fibroproliferative disorder of the palmar and digital fascia, whereby a thick collagen cord develops, causing flexion deformity, or contracture of the affected metacarpophalangeal or proximal interphalangeal joints known as Dupuytren’s contracture (DC). The pathogenesis of DD is largely genetic, and the complexities of its underlying cellular and subcellular mechanisms are only starting to be understood. Surgery has been the mainstay of treatment for DC for centuries; however, less invasive approaches have been shown to be effective in more recent clinical trials and in clinical practice. Unfortunately, many surgeons are not aware of this evidence. Moreover, there is a lack of clear guidance on the optimal techniques and treatment algorithms for on- and off-label use of available therapies, leaving surgeons without definitive direction to achieve the best patient outcomes. DC is a relatively prevalent condition and has a significant negative impact of affected patients in terms of appearance and hand function deficits. Thus, a better understanding of DC management is essential. This CME-certified initiative will feature a panel of prominent experts, who will educate on advances and evidence for treating DC.

Learning Objectives
Upon completion of this activity, participants should be able to:

  • Detail a treatment algorithm for DC incorporating best practices based on the most recent high-quality evidence to streamline the decision-making process for customized patient care.
  • Describe the evidence regarding the benefits of CCH injections to treat DC, including its efficacy and safety.
  • Implement appropriate injection technique when using CCH to treat DC.

Physician Accreditation Statement
Paradigm Medical Communications, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Physician Credit Designation Statement
Paradigm Medical Communications, LLC designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

PA Continuing Education
PAs may claim a maximum of 1.0 Category 1 credits for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society.

Nurse Practitioner Continuing Education
The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.

Instructions for Participation 
To receive a CME certificate of participation, you should:

  • Follow instructions to register or log in with your professional information and complete the pre-activity assessment
  • View the online activity in its entirety
  • Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest

A certificate of participation will be available for download/printing immediately following your successful completion of the posttest and evaluation.

For questions regarding CME credit, contact the Paradigm CME Department at (845) 398-5949 or cme@paradigmmc.com.

There is no fee required for participation in this activity.

Hardware/Software Requirements
This certified CME activity is designed using HTML5 web components. As you navigate the video using the supplied controls, the slides will sync to the speaker.

Supported Browsers (Desktop/Mobile)
Chrome 45+, Firefox 40+, Edge, Edge Chromium, Safari 8+, Opera 31+

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Disclosures
In accordance with ACCME requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in the activity. These relationships are described below. Any potential conflicts of interest have been resolved.

Lawrence C. Hurst, MD (Chair)
Royalty: BTC Corporation

Philip Blazar, MD
No financial relationships to disclose

Samantha I. Muhlrad, MD 
No financial relationships to disclose

Paradigm Medical Communications, LLC staff members have no financial relationships to disclose.

Independent peer reviewer has no financial relationships to disclose.

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Paradigm Medical Communications, LLC has implemented a system to resolve conflicts of interest for each CME activity to help ensure content is objective, fair and balanced, independent, and aligned with the public interest. Conflicts, if any, are resolved through one or more processes. All CME content in this activity was independently reviewed to ensure that it is free of commercial bias, scientifically rigorous, aligned with the public interest, and compliant with all regulatory guidance and the ACCME’s Standards for Commercial Support of Continuing Medical Education.

Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not approved by the FDA.

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