CONTINUING MEDICAL EDUCATION INFORMATION
 
Release Date: September 5, 2013
Last Reviewed: July 17, 2013
Expiration Date: September 5, 2014
Time to Complete Activity:  2 hours
 
Faculty
Robert H. I. Andtbacka, MD, CM
Assistant Professor of Surgery
Division of Surgical Oncology
University of Utah School of Medicine
Surgeon and Investigator
Huntsman Cancer Institute
Salt Lake City, UT
 
Kenneth F. Grossmann, MD, PhD
Assistant Professor
Division of Oncology
Department of Medicine
University of Utah
Medical Oncologist and Investigator
Melanoma and Cutaneous Oncology Program
Huntsman Cancer Institute
Salt Lake City, UT
 
Hung Khong, MD
Associate Professor
Division of Oncology
University of Utah School of Medicine
Investigator
Huntsman Cancer Institute
Salt Lake City, UT
 
Merrick I. Ross, MD
Professor of Surgery
Chief, Melanoma Section
Charles M. McBride Distinguished Professor
Department of Surgical Oncology
University of Texas MD Anderson Cancer Center
Houston, TX
 
Target Audience
This activity has been designed to meet the educational needs of community and other physicians specializing in oncology, surgical oncology, radiation oncology, and other specialties involved in the management of patients with melanoma. Other healthcare professionals with an interest in melanoma may also benefit from this initiative.
 
Statement of Need
An abundance of data from melanoma clinical trials—some of which have advanced to phase 3—indicate that intralesional agents exploiting the principles of oncolytic immunotherapy hold the promise of improved survival for patients with regional or metastatic disease along with excellent tolerability profiles compared with those of systemic agents. These intralesional agents have a unique mechanism of action, mode of administration, and other characteristics that oncologists may be unfamiliar with, complicating assessment of their benefits and risks. This program is designed to enhance participant understanding of the concepts and data supporting these new intralesional therapies and provide strategies for selecting appropriate patients and evaluating treatment response, facilitating integration of these agents into mainstream melanoma therapy.
 
Educational Objectives
Upon proper completion of this activity, participants should be better able to:
  • Describe the mechanisms of action of new intralesional agents and appropriate administration techniques
  • Formulate melanoma treatment plans that integrate intralesional therapies with other established therapies for appropriate patients
  • Differentiate between the response to immunotherapies and response to cytotoxic therapies in patients with melanoma
 
Disclosures
In accordance with Accreditation Council for Continuing Medical Education requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in the activity. These relationships are described below.

Robert H. I. Andtbacka, MD, CM
Grant/Research Support: Amgen Inc.; Takeda Pharmaceutical Company Limited; Vical Inc.; Viralytics Limited
Retained Consultant: Amgen Inc.; Vical Inc.
 
Kenneth F. Grossmann, MD, PhD
Advisory Board: Prometheus
 
Hung Khong, MD
No financial relationships to disclose.
 
Merrick I. Ross, MD
Advisory Board: GlaxoSmithKline; Merck & Co., Inc.
Speakers Bureau: Amgen Inc.; Genomic Health; GlaxoSmithKline
 
Paradigm Medical Communications, LLC staff members have no financial relationships to disclose.

Independent peer reviewer has no financial relationships to disclose.
 
Accreditation Statement
Paradigm Medical Communications, LLC is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
 
Credit Designation Statement
Paradigm Medical Communications, LLC designates this enduring material for a maximum of 2.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
 
Disclosure of Commercial Support
This activity is supported by an educational donation provided by Amgen.
 
Instructions for Participation
To receive a CME certificate of participation, participants should:
  • Follow instructions to register or log in with your professional information and complete the pretest.
  • View the online activity in its entirety.
  • Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest.
  • A certificate of participation will be available for download/printing immediately following your successful completion of the posttest and evaluation.
 
There is no fee required for participation in this activity.

HARDWARE/SOFTWARE REQUIREMENTS
This certified CME activity is designed as a self-running Flash presentation.  In the event that you need this plug-in, a link to download the required Flash Player has been provided below.
 
Flash Player 10 or later required–download athttp://www.adobe.com/support/flashplayer/downloads.html
 
For your convenience, a control bar is located at the bottom of the slide that provides buttons to move forward and backwards through the deck. 
 
Supported Browsers:
For Windows: Internet Explorer 7 or higher, Firefox 4.0, Safari 3, Google Chrome, Opera 9.5
For Mac: Safari 3, Firefox 4.0, Google Chrome
Linux: Firefox 4.0
 
Technical Support: If you have any technical problems or playback issues, please send an email tocontactus@paradigmmc.comor call (845) 398-5100.
 
Resolution of Conflict of Interest
Paradigm Medical Communications, LLC has implemented a system to resolve conflicts of interest for each continuing medical education activity to help ensure content objectivity, independence, fair balance, and that the content is aligned with the interest of the public. Conflicts, if any, are resolved through one or more processes. All CME content in this activity was independently reviewed to ensure that it is free of commercial bias, scientifically rigorous, aligned with the public interest, and compliant with all regulatory guidance and the ACCME’s Standards for Commercial Support of Continuing Medical Education.
 
© 2013 Paradigm Medical Communications, LLC, except where noted. This web presentation may not be reproduced in whole or part without the express written permission of Paradigm Medical Communications, LLC.
 
DISCLAIMER
This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. Reasonable efforts have been taken to present educational subject matter in a balanced, unbiased fashion, and in compliance with regulatory requirements. However, each activity participant must always use his or her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.
 
Terms of Use and Privacy Policy
Privacy policy
Paradigm Medical Communications, LLC is committed to protecting the privacy of those who choose to participate in the activities (herein referred to as "website") located at www.paradigmmc.com. This information below describes the security of the website for safeguarding personal information and the rationale for collection and use of personal information.

Security/safeguarding personal information
This website has physical and procedural safeguards in place to prevent unauthorized access to personal information used to access this website.

Collection and use of personal information
To earn CME credits using the website, the submission of certain personally identifiable information is necessary. The required items include: first name, last name, degree, and e-mail address. These items are necessary to award and track the credits and participants may earn after completing the program. Participants are required to complete an evaluation of the CME activity. All evaluative information submitted is collected and retained, and assists the staff of Paradigm Medical Communications, LLC in continuously improving the learning experience.

Paradigm Medical Communications, LLC does not transfer, sell, or share personal information with outside parties. Paradigm Medical Communications, LLC will not otherwise disclose personal information unless required to in a legal process. Paradigm Medical Communications, LLC staff members review individual test results to the extent necessary to record and track participant's credits.

Contact Us
If you have any questions or comments regarding this policy, please send an email to contactus@paradigmmc.com