The Evolving Role of Beta Blockers in the Management of Hypertension—Expert Perspectives 

Release Date: January 30, 2014
Last Reviewed: December 9, 2013
Expiration Date: January 30, 2015
Time to Complete Activity:  1.75 hours

*This activity expired for credit on January 30, 2015 and is no longer available for credit

Keith C. Ferdinand, MD
Professor of Clinical Medicine
Tulane University School of Medicine
Tulane Heart and Vascular Institute
New Orleans, LA
Kenneth A. Jamerson, MD, FAHA, FASH
Professor of Internal Medicine
Frederick G.L. Huetwell Collegiate Professor of Cardiovascular Medicine
University of Michigan Health System
Department of Cardiovascular Medicine
Ann Arbor, MI
Franz H. Messerli, MD
Professor of Medicine
Columbia University
St. Luke’s Roosevelt Hospital Center
Department of Cardiology
New York, NY
Michael Weber, MD
Professor of Medicine
SUNY Downstate College of Medicine
Cardiology Department
Brooklyn, NY
This activity has been designed to meet the educational needs of primary care physicians, internists, hospitalists, physician assistants, and other allied HCPs interested and actively engaged in the management of patients with hypertension.
For nearly half a century, beta-blockers (BBs) have been a pivotal mainstay in the management of hypertension. Yet, there is still some confusion as to the differences among the agents, the data supporting their use, and patient selection. BBs are not a homogenous class of drugs, and many of the therapeutic limitations prompting guideline changes may not be present in third-generation agents. Unlike earlier BBs, select third-generation BBs exert direct vasodilatory effects by improving endothelial function and mediating the release of nitric oxide, a potent vasodilator. Data suggest that newer agents are not associated with many of the common side effects of early-generation BBs, and that they may have a particular role among difficult-to-treat patient populations. Questions regarding their efficacy and tolerability have raised concerns about how best to use BBs, ie, which to prescribe and for what patient type. To address these concerns, The Evolving Role of Beta-Blockers in the Management of Hypertension—Expert Perspectives has been developed for primary care physicians. The purpose of this webinar is to examine the utility of BBs in the management of hypertension through a review of contemporary, evidence-based data on their use as an essential tool in the clinician’s fight to appropriately treat patients diagnosed with hypertension. The focus is on the contemporary role of BBs in the management of hypertension, differences among the various agents, and patient selection criteria—which agents to choose and for whom—in a lively roundtable discussion among the experts.
After completing this activity, the participant should be better able to:
  • Describe differences among first-, second-, and third-generation beta-blockers and, particularly, the differences between older agents and new vasodilating third-generation agents.
  • Review meta-analyses and clinical trials informing current guideline recommendations to determine if and when beta-blockers should be used for the management of patients with hypertension.
  • Describe the mechanisms of action and clinical data demonstrating efficacy and safety of newer beta-blockers for consideration in the treatment of patients with hypertension.
2 minutes
Chapter 1
Hypertension in the US:  Is There Still a Role for Beta-Blockers?
7 minutes
Chapter 2
Understanding the Differences
25 minutes
Chapter 3
Beta-Blockers in Hypertension:  The Data For and Against
24 minutes
Chapter 4
Vasodilating Beta-Blockers
28 minutes
Chapter 5
Case Study
8 minutes
Chapter 6
Conclusions:  Continuing Utility of Beta-Blockers
4 minutes
In accordance with Accreditation Council for Continuing Medical Education requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in the activity. These relationships are described below.
Name of Faculty or Presenter
Reported Financial Relationship
Keith C. Ferdinand, MD
Consulting Fees: Daiichi Sankyo, Inc.; Forest Laboratories, Inc.; Takeda Pharmaceutical Company Ltd.
Speakers Bureau: AstraZeneca Pharmaceuticals; Takeda Pharmaceutical Company Ltd.
Research: AstraZeneca Pharmaceuticals
Kenneth A. Jamerson, MD, FAHA, FASH
Consulting Fees:AstraZeneca Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.; Novartis Corporation; Takeda Pharmaceutical Company Ltd.
Speakers Bureau: Daiichi Sankyo, Inc.
Research: National Heart, Lung, and Blood Institute; National Institutes of Health; National Institute of Diabetes & Digestive & Kidney Diseases; Novartis Corporation
Board/Committee Member: American Society of Hypertension; International Society of Hypertension in Blacks
Franz H. Messerli, MD
Consulting Fees: Abbott Laboratories; Daiichi Sankyo, Inc.; Ipca Laboratories Ltd.; Medtronic, Inc.; Novartis Corporation; Pfizer Inc.; Laboratoires Servier; Takeda Pharmaceutical Company Ltd.
Michael Weber, MD
Consulting Fees: Boehringer Ingelheim Pharmaceuticals, Inc.; Daiichi Sankyo, Inc.; Forest Laboratories, Inc.; Medtronic; Boston Scientific;
Takeda Pharmaceutical Company Ltd.
Speakers’ Bureau: Daiichi Sankyo, Inc.; Forest Laboratories, Inc.; Takeda Pharmaceutical Company Ltd.
Paradigm Medical Communications, LLC staff members have no financial conflicts to disclose.
Independent peer reviewer has no financial conflicts to disclose.
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Paradigm Medical Communications, LLC designates this enduring material for a maximum of 1.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
This activity is supported by an educational grant from Forest Laboratories, Inc.
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