Update on Febrile Neutropenia Prophylaxis:
Expert Perspectives on Appropriate Use and Cost-Effective Choices
Release Date: August 18, 2014
Last Reviewed: July 29, 2014
Expiration Date: August 18, 2015
Time to Complete Activity: 1 hour

*This activity expired for credit on August 18, 2015 and is no longer available for credit
Neil A. Davis, PharmD
Clinical Pharmacy Coordinator
Critical Care Clinical Specialist
Residency Program Director
Sentara Healthcare
Virginia Beach, VA
Associate Clinical Professor
Virginia Commonwealth University School of Pharmacy
Richmond, VA
Ashley Morris Engemann, PharmD, BCOP, CPP
Clinical Associate
Department of Medicine
Division of Hematologic Malignancies and Cellular Therapy
Duke University School of Medicine
Durham, NC
LeAnne D. Kennedy, PharmD, BCOP, CPP
Pharmacy Clinical Specialist, Adult Hematology and Oncology
Department of Pharmacy
Wake Forest University Baptist Medical Center
Winston-Salem, NC
Target Audience
This activity has been designed to address the educational needs of health-system pharmacists and clinical pharmacists specializing in oncology.
Learning Objectives
Upon proper completion of this knowledge-based activity, participants should be better able to:
  • Recognize guideline-concordant uses of myeloid CSF agents available for febrile neutropenia prophylaxis, based on identification of risk factors
  • Describe strategies for minimizing the high cost burden associated with febrile neutropenia
Agenda/Table of Contents
  • Introduction
  • Febrile Neutropenia Pathophysiology
  • Consequences of Febrile Neutropenia
  • Treatment of Established Febrile Neutropenia
  • Identifying Candidates for Febrile Neutropenia Prophylaxis
  • The Role of Antimicrobials for Febrile Neutropenia Prophylaxis
  • An Algorithmic Approach to Myeloid Growth Factors
  • Comparison of New and Traditional Agents for Febrile Neutropenia Prophylaxis: Indications, Dosing, and Costs
  • Timing and Duration of Myeloid CSF Prophylaxis
  • Summary
Accreditation Statement
This activity is cosponsored by the University of North Carolina Eshelman School of Pharmacy and Paradigm Medical Communications, LLC. The University of North Carolina Eshelman School of Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.




Credit Designation Statement
This activity, UAN 0046-9999-14-124-H01-P, will provide 1.0 contact hour or 0.1 CEU for viewing this web-based home study activity in its entirety, achieving a score of 70% or higher on the posttest, and completing an activity evaluation.
ACPE Credit
Upon fulfillment of the participation requirements, verification of credit will be maintained with the UNC Eshelman School of Pharmacy and a record of successful completion of this activity will be submitted to ACPE/NABP’s CPE Monitor. Only learners who provide valid NABP e-Profile ID numbers and PIN numbers (month and date of birth) in their registration information within 45 days of submitting for credit will be submitted to ACPE/NABP’s CPE Monitor for official record of credit. Pharmacy learners who do not provide this information will not be eligible to receive credit.
Disclosure of Commercial Support
This CPE activity is supported by an educational grant from Teva Pharmaceuticals.
Faculty Disclosures
In accordance with Accreditation Council for Pharmacy Education requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in the activity. These relationships are described below.
Neil A. Davis, PharmD
No financial relationships to disclose
Ashley Morris Engemann, PharmD, BCOP, CPP
No financial relationships to disclose
LeAnne D. Kennedy, PharmD, BCOP, CPP
No financial relationships to disclose
Paradigm Medical Communications, LLC staff members have no financial conflicts to disclose.
The UNC Eshelman School of Pharmacy staff members have no relevant financial conflicts to disclose.
Instructions for Participation
To receive CPE certificate of participation, participants should:
  • Follow instructions to register or log in with your professional information and complete the pretest
  • View the online activity in its entirety.
  • Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest.
  • A statement of completion will be available for download/printing immediately following your successful completion of the posttest and evaluation.
There is no fee required for participation in this activity.
For questions regarding CPE credit, contact the Paradigm CME department at (845) 398-5949.
Hardware/Software Requirements
Supported Browsers
Internet Explorer 7+, Firefox 4+, Safari 3+, Chrome 1+, Opera 9+

Adobe Reader
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Resolution of Conflict of Interest
University of North Carolina Eshelman School of Pharmacy and Paradigm Medical Communications, LLC has implemented a system to resolve conflicts of interest for each CPE activity to help ensure content is objective, independent, fairly balanced, and aligned with the public interest. Conflicts, if any, are resolved through one or more processes. All CPE content in this activity has been independently reviewed to ensure that it is free of commercial bias, scientifically rigorous, aligned with the public interest, and compliant with all regulatory guidance and the ACPE’s Standards and Guidelines.
Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA.
This CPE activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC, and The University of North Carolina Eshelman School of Pharmacy. Reasonable efforts have been taken to present educational subject matter in a balanced, unbiased fashion, and in compliance with regulatory requirements. However, each activity participant must always use his or her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.
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The materials provided for this activity are for informational purposes only, and should not be used for diagnosis or treatment of a health problem without consulting a licensed medical professional. Any views or opinions presented are solely those of the Faculty, and do not necessarily represent those of Paradigm Medical Communications, LLC or the University of North Carolina Eshelman School of Pharmacy. References to any entity, product, service, or source of information on this website should not be considered an endorsement, either direct or implied, by Paradigm Medical Communications, LLC. Paradigm Medical Communications, LLC accepts no liability for the content referenced in this activity.
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This website has physical and procedural safeguards in place to prevent unauthorized access to personal information used to access this website.
Collection and use of your personal information
The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing the program. Required items include first name, last name, degree, and email address. These items are necessary. Participants are also required to complete an evaluation of the CME activity. All evaluative information submitted is collected and retained, and used by Paradigm Medical Communications, LLC to continuously improve the learning experience.
Paradigm Medical Communications, LLC and the University of North Carolina Eshelman School of Pharmacy do not transfer, sell, or share personal information with outside parties. Paradigm Medical Communications, LLC and the University of North Carolina Eshelman School of Pharmacy will not otherwise disclose personal information unless required to in a legal process. Paradigm Medical Communications, LLC and the University of North Carolina Eshelman School of Pharmacy staff members review individual test results to the extent necessary to record and track participants’ credits.
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