Release Date: November 3, 2023
Expiration Date: November 3, 2024
Time to Complete Activity: 0.75 hour

Faculty

Heather Han, MD—Chairperson 
Associate Member
Clinical Research Director
Department of Breast Oncology 
Moffitt Cancer Center
Associate Professor
University of South Florida College of Medicine
Tampa, FL

Saeed N. Bajestani, MD
Associate Professor 
Departments of Oncological Sciences and Pathology
Associate Program Director and Site Director at Moffitt Cancer Center, University of South Florida Pathology Residency Training Program
Breast Pathology
Moffitt Cancer Center
University of South Florida College of Medicine 
Tampa, FL

Ricardo L. Costa, MD, MSc
Assistant Member
Department of Breast Oncology
Moffitt Cancer Center
Assistant Professor
University of South Florida College of Medicine
Tampa, FL

Hatem H. Soliman, MD
Associate Member
Breast Oncology, Immunology, Tumor Biology Departments
Medical Director, Clinical Trials Office and Phase 1 Program
Moffitt Cancer Center 
Associate Professor
University of South Florida College of Medicine
Tampa, FL

Activity Description

Assessment of HER2 expression has been a mainstay of breast cancer (BC) management for decades, yet the concept of HER2-low has only recently emerged as an actionable biomarker. This expert faculty discussion includes a perspective from a pathologist, and sheds light on how to interpret HER2 test results and apply them to treatment selection for metastatic BC. The program also includes discussion regarding treatment sequencing and management of adverse events, as well as the latest data on trastuzumab deruxtecan (T-DXd) and other emerging agents that target HER2-low.

Learning Objectives

At the completion of this program, learners will be better able to--

1. Summarize the latest information on the classification of HER2 among breast tumors, with a focus on the category of HER2-low
2. Apply the latest clinical trial data to treatment decisions for patients with HER2-low–expressing, relapsed/refractory BC

Target Audience

This activity has been designed to meet the educational needs of medical oncologists, pathologists, pharmacists, nurses, advanced practice providers, fellows, residents, and other clinicians involved in the care of patients with metastatic BC.

Disclosures

USF Health adheres to the Accreditation Council for Continuing Medical Education’s (ACCME) Standards for Integrity and Independence in Accredited Continuing Education. All individuals in a position to influence content have disclosed to USF Health any financial relationship with an ineligible organization. USF Health has reviewed and mitigated all relevant financial relationships related to the content of the activity. The relevant financial relationships are listed below.

Faculty
Saeed N. Bajestani, MD
Has no relevant financial relationships with ineligible companies to disclose.

Ricardo L. Costa, MD, MSc: Advisory board or panel fees from AstraZeneca and Daiichi Sankyo, relationships ended.
Speaker’s bureau fees from AstraZeneca, Daiichi Sankyo, and Pfizer, relationships ended.

Heather Han, MD: Grants/research support from Abbvie, Arvinas, Bristol Myers Squibb, G1 Therapeutics, Marker Therapeutics, Novartis, Pfizer, Pionyr Immunotherapeutics, Quantum Leap Healthcare Collaborative, Seagen, Senhwa Biosciences, and Zymeworks.

Hatem H. Soliman, MD: Advisory board or panel fees from AstraZeneca, Eisai, Eli Lilly, Novartis, Pfizer, Puma Biotechnology, Seagen, and Sermonix Pharmaceuticals. Speaker’s Bureau fees from Merck, relationship ended.

Content Reviewer
Alicia Canalejo, APRN has no financial interests/relationships or affiliations in relation to this activity.
Jasmine Cutler, PharmD, CPh has no financial interests/relationships or affiliations in relation to this activity.

Staff
USF Health Office of Continuing Professional Development and Paradigm Medical Communications, LLC staff have no relevant financial interests/relationships or affiliations in relation to this activity.

Requirements for Successful Completion

To receive a certificate of participation, participants must:

• Follow instructions to register or log in with your professional information and complete the preassessment
• View the online activity in its entirety
• Complete and submit the online postassessment and evaluation. You must answer 70% of the postassessment questions correctly to earn credit. You will have unlimited opportunities to successfully complete the postassessment

A certificate of participation will be available for download/printing immediately following your successful completion of the postassessment and evaluation.

If you have questions regarding credit, please contact cpdsupport@usf.edu.

Accreditations

Physicians

USF Health is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

USF Health designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit^™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The European Union of Medical Specialists (UEMS)–European Accreditation Council for Continuing Medical Education (EACCME) has an agreement of mutual recognition of continuing medical education (CME) credit with the American Medical Association (AMA). European physicians interested in converting AMA PRA Category 1 Credit™ into European CME credit (ECMEC) should contact the UEMS (www.uems.eu).

Advanced Practice Providers

Physician Assistants may claim a maximum of 0.75 Category 1 credit for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society.

The AANPCP accepts certificates of participation for educational activities approved for AMA PRA Category 1 Credit™ by ACCME-accredited providers. APRNs who participate will receive a certificate of completion commensurate with the extent of their participation.

Nurses

USF Health is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.

A maximum of 0.75 contact hour may be earned by learners who successfully complete this continuing nursing education activity. USF Health, the accredited provider, acknowledges Paradigm Medical Communications, LLC as the partner in the planning and execution of this CNE activity.

This activity is awarded 0.75 ANCC pharmacotherapeutic contact hour.

Pharmacists

USF Health is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. This knowledge-based program has been approved for 0.75 contact hours (0.075 CEU). Universal program number is as follows: (0230-0000-23-021-H01-P).

Date of original release: November 3, 2023. Date credit expires: November 3, 2024.

If you have any questions regarding credit, please contact cpdsupport@usf.edu.

This Activity Is Funded By:

An independent medical education grant from Daiichi Sankyo, Inc, and AstraZeneca.

Educational Provider: 

This activity is provided by USF Health in partnership with Paradigm Medical Communications, LLC and Moffitt Cancer Center.
   

The information provided by this CE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

USF is an Equal Opportunity/Affirmative Action/Equal Access Institution.

USF Health is accredited by the Accreditation Council for Continuing Medical Education, the American Nurses Credentialing Center, and the Accreditation Council for Pharmacy Education to provide continuing education to healthcare professionals. As an accredited provider, USF Health is required to disclose personal information to relevant accredited bodies that certify CE to process credits/contact hours, comply with reporting requirements, and for internal recordkeeping and regulatory purposes. USF Health does not share or sell any individual’s contact information or unique identifiers to any commercial supporter, advertiser, or third party without the specific permission of the individual.

Hardware/Software Requirements

This accredited CME activity is designed using HTML5 web components. As you navigate the video using the supplied controls, the slides will sync to the speaker.

Supported Browsers (Desktop/Mobile)
Chrome 45+, Firefox 40+, Edge, Edge Chromium, Safari 8+, Opera 31+

PDF documents
This activity may contain PDF documents. Most current browsers support viewing of PDFs natively, but you may also download a free version of Adobe Acrobat Reader here: http://get.adobe.com/reader

Technical Support
If you have any technical problems or playback issues, email us at contactus@paradigmmc.com.

Disclaimer

This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, USF Health and Paradigm Medical Communications, LLC. Reasonable efforts have been taken to present educational subject matter in a balanced, unbiased fashion, and in compliance with regulatory requirements. However, each activity participant must always use his or her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

If included, signed statements of informed consent granting permission for publication have been obtained for all photographs and videos in which an individual can be identified.

Terms of Use and Privacy Policy
Disclaimer
The materials provided for this activity are for informational purposes only and should not be used for diagnosis or treatment of a health problem without consulting a licensed medical professional. This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, USF Health and Paradigm Medical Communications, LLC. References to any entity, product, service, or source of information on this website should not be considered an endorsement, either direct or implied, by USF Health and Paradigm Medical Communications, LLC. USF Health and Paradigm Medical Communications, LLC accept no liability for the content referenced in this activity.

Privacy policy
Paradigm Medical Communications, LLC or hosted contracted partner is committed to protecting the privacy of those who participate in the activities located at www.paradigmmc.com (herein referred to as “website”). The information below describes the security of the website for safeguarding personal information and the rationale for collection and use of personal information.

Security/safeguarding personal information
This website has physical and procedural safeguards in place to prevent unauthorized access to personal information used to access this website.

Collection and use of your personal information
The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing the program. Required items include first name, last name, degree, and email address. These items are necessary. Participants are also required to complete an evaluation of the CME activity. All evaluative information submitted is collected and retained, and used by Paradigm Medical Communications, LLC to continuously improve the learning experience.

Paradigm Medical Communications, LLC does not transfer, sell, or share personal information with outside parties. Paradigm Medical Communications, LLC will not otherwise disclose personal information unless required to in a legal process. Paradigm Medical Communications, LLC staff members review individual test results to the extent necessary to record and track participants’ credits.

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