The Critical Role of Pathology in the Diagnosis of Castleman Disease

Release Date: November 5, 2021
Expiration Date: November 5, 2022
Time to Complete Activity: 1.0 hour
*This activity expired for credit on November 5, 2022 and is no longer available for credit


Ahmet Dogan, MD, PhD—Chairperson
Chief, Hematopathology Service
Departments of Pathology and Laboratory Medicine
Memorial Sloan Kettering Cancer Center
New York, NY 

Daisy Alapat, MD
Associate Professor
University of Arkansas for Medical Sciences
Little Rock, AR

Amy Chadburn, MD
Professor of Pathology and Laboratory Medicine
Weill Cornell Medicine
New York, NY

Joseph Khoury, MD
Department of Hematopathology
Division of Pathology and Lab Medicine
The University of Texas MD Anderson Cancer Center
Houston, TX

This activity is provided by Paradigm Medical Communications, LLC.  
In collaboration with the Castleman Disease Collaborative Network. 

Disclosure of Financial Support
This activity is supported by an educational grant from EUSA Pharma (US) LLC.

Target Audience
This activity has been designed to address the educational needs of hematopathologists and other pathologists involved in the diagnosis of Castleman disease (CD). It will also benefit other clinicians interested in the management patients with CD.

Statement of Need
CD is a rare group of heterogeneous lymphoproliferative disorders, including unicentric CD and subtypes of multicentric CD (MCD), many of which have an unknown underlying etiology. Owing to its rarity and unknown etiology, and a historical lack of clinical practice guidelines, pathologists may find the recognition and diagnosis of this disease challenging. This engaging program features expert pathologists who highlight critical information that is needed to identify CD, including a focus on all aspects of histopathology and clinical characteristics needed to make an accurate diagnosis. 

Learning Objectives
Upon completion of this activity, participants should be able to:

  • Review the pathophysiology of CD, including similarities and differences among the histopathologic subtypes
  • Appraise histopathologic features of CD, including variants of idiopathic MCD (iMCD), to correctly identify CD in patients
  • Devise a communication plan between the pathologist and hematology/oncology clinicians regarding the need for an appropriate biopsy for an accurate diagnosis of CD


  • Introduction to CD—Ahmet Dogan, MD, PhD
  • Unicentric CD—Joseph Khoury, MD
  • MCD With Specific Etiology—Amy Chadburn, MD
  • iMCD—Daisy Alapat, MD
  • Faculty Panel Discussion

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  • Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest

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In accordance with ACCME requirements on disclosure, faculty and contributors are asked to disclose any financial relationships occurring over the past 24 months with ineligible companies whose products or services are associated with the area of medicine featured in the activity. These relationships are described below. Any potential conflicts of interest have been mitigated.

Ahmet Dogan, MD, PhD—Chairperson
Research Funding: F. Hoffmann-La Roche Ltd; Takeda Pharmaceutical Company Ltd

Daisy Alapat, MD 
No relevant financial relationship(s) with ineligible companies to disclose

Amy Chadburn, MD
No relevant financial relationship(s) with ineligible companies to disclose

Joesph Khoury, MD
Advisor: ANGLE plc.
Consulting Fees: Dren Bio; Gilead Sciences, Inc
Research Funding: Arcus Biosciences, Inc.; NovalGen
Independent Contractor: Theradex Systems, Inc.

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Independent peer reviewer has no relevant financial relationship(s) with ineligible companies to disclose.

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