Update on the Treatment of HER2-Low and HER2-Ultralow Metastatic Breast Cancer



Release Date: July 18, 2025
Expiration Date: July 18, 2026
Time to Complete Activity: 0.75 hour

Faculty 

Saeed N. Bajestani, MD, FCAP—Chairperson
Associate Professor
Departments of Oncological Sciences and Pathology
Associate Program Director and Site Director
Moffitt Cancer Center
University of South Florida Pathology Residency Training Program
Breast Pathology
Moffitt Cancer Center
USF College of Medicine
Chair, House of Delegates for Florida, College of American Pathologists
Tampa, FL

Sara A. Hurvitz, MD, FACP
Professor of Medicine
Head, Division of Hematology and Oncology
Senior Vice President, Clinical Research Division
Department of Medicine, UW Medicine
Fred Hutchinson Cancer Center
Seattle, WA
 

Target Audience 

This activity has been designed to address the educational needs of medical oncologists. This activity may be of interest to pathologists, oncology and pathology nurse practitioners and PAs, and other clinicians who are involved in the management of patients with metastatic breast cancer (mBC).
 

Educational Provider

This activity is provided by USF Health in partnership with Paradigm Medical Communications, LLC and Moffitt Cancer Center.

      
 

Supporter Acknowledgment 

This activity is funded by independent medical education grants from Daiichi Sankyo, Inc and AstraZeneca.

 
Program Overview

Review the latest advancements in human epidermal growth factor receptor 2 (HER2)-ultralow mBC by joining this in-depth discussion between leading pathology and medical oncology experts. Learn how a new drug indication as well as updated ASCO/CAP guidelines for HER2-low and -ultralow classifications will redefine the way patients with HER2 mBC are both diagnosed and treated.
 

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Apply the latest clinical trial data to treatment decisions for patients with HER2-low or HER2-ultralow–expressing, relapsed/refractory breast cancer 
  • Implement monitoring and treatment strategies for common and agent-specific adverse events in patients treated with antibody-drug conjugates


Physicians

USF Health is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

USF Health designates this enduring activity for a maximum of 0.75 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The European Union of Medical Specialists (UEMS)—European Accreditation Council for Continuing Medical Education (EACCME) has an agreement of mutual recognition of continuing medical education (CME) credit with the American Medical Association (AMA). European physicians interested in converting AMA PRA Category 1 CreditTM into European CME credit (ECMEC) should contact the UEMS (www.uems.eu).
 

Advanced Practice Providers

Physician Assistants may claim a maximum of 0.75 Category 1 credit for completing this activity. NCCPA accepts AMA PRA Category 1 CreditTM from organizations accredited by ACCME or a recognized state medical society.

The AANPCP accepts certificates of participation for educational activities approved for AMA PRA Category 1 CreditTM by ACCME-accredited providers. APRNs who participate will receive a certificate of completion commensurate with the extent of their participation.
 

Hardware/Software Requirements

This accredited CME activity is designed using HTML5 web components. As you navigate the video using the supplied controls, the slides will sync to the speaker.
Supported Browsers (Desktop/Mobile)
Chrome 45+, Firefox 40+, Edge, Edge Chromium, Safari 8+, Opera 31+
PDF documents
This activity may contain PDF documents. Most current browsers support viewing of PDFs natively, but you may also download a free version of Adobe Acrobat Reader here: http://get.adobe.com/reader

Technical Support: If you have any technical problems or playback issues, email us at contactus@paradigmmc.com.


Instructions for Participation

To receive a certificate of participation, participants must:

  • Follow instructions to register or log in with your professional information and complete the pretest
  • View the online activity in its entirety
  • Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest

A certificate of participation will be available for download/printing immediately following your successful completion of the posttest and evaluation.

For questions regarding CME credit, please contact cpdsupport@usf.edu.

There are no fees for participating in this activity.
 

Disclosure of Relevant Financial Relationships

USF Health adheres to the Accreditation Council for Continuing Medical Education’s (ACCME) Standards for Integrity and Independence in Accredited Continuing Education. All individuals in a position to influence content have disclosed to USF Health any financial relationship with an ineligible organization. USF Health has reviewed and mitigated all relevant financial relationships related to the content of the activity. The relevant financial relationships are listed below.

Saeed N. Bajestani, MD, FCAP 
Has no relevant financial relationships with ineligible companies to disclose.

Sara A. Hurvitz, MD, FACP: Advisory board or panel fees from Arvinas, Beigene, Boerhinger Ingelheim, BriaCell, Jazz Pharmaceuticals, and Luminate Medical. Grants/research support from Ambrx, Amgen,  Arvinas, Astra Zeneca, Bayer, Celcuity, Cytomx, Daiichi-Sankyo, Dantari, Dignitana, Eli Lilly, G1-Therapeutics, Genentech/Roche, Gilead, Greenwich Life Sciences, GSK, Immunomedics, LOXO, Macrogenics, Novartis, OBI Pharma, Orinove, Orum, Pfizer, Phoenix Molecular Designs, Pieris, Puma Biotechnology, Radius Health, Samumed, Sanofi, Seattle Genetics/Seagen, and Zymeworks.

Content Reviewer
Danielle Walker, DNP, APRN, AGNP-C 
Has no financial interests/relationships or affiliations in relation to this activity.

Staff
USF Health Office of Continuing Professional Development and Paradigm Medical Communications, LLC staff have no relevant financial interests/relationships or affiliations in relation to this activity.
 

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not approved by the FDA.

The information provided by this CME activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

USF is an Equal Opportunity/Affirmative Action/Equal Access Institution.

USF Health is accredited by the Accreditation Council for Continuing Medical Education to provide continuing education to healthcare professionals. As an accredited provider, USF Health is required to disclose personal information to relevant accredited bodies that certify CME to process credits/contact hours, comply with reporting requirements, and for internal recordkeeping and regulatory purposes. USF Health does not share or sell any individual’s contact information or unique identifiers to any commercial supporter, advertiser, or third party without the specific permission of the individual.
 

Disclaimer

This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, USF Health and Paradigm Medical Communications, LLC. Reasonable efforts have been taken to present educational subject matter in a balanced, unbiased fashion, and in compliance with regulatory requirements. However, each activity participant must always use his or her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

If included, signed statements of informed consent granting permission for publication have been obtained for all photographs and videos in which an individual can be identified.

As ACCME-accredited providers, USF Health and Paradigm Medical Communications, LLC must ensure that their activities include a balanced view of therapeutic options. Use of generic names contributes to this impartiality. The use of trade names should not be viewed as an endorsement of specific products by USF Health or Paradigm Medical Communications, LLC. 

Terms of Use and Privacy Policy
Disclaimer
The materials provided for this activity are for informational purposes only and should not be used for diagnosis or treatment of a health problem without consulting a licensed medical professional. This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, USF Health and Paradigm Medical Communications, LLC. References to any entity, product, service, or source of information on this website should not be considered an endorsement, either direct or implied, by USF Health and Paradigm Medical Communications, LLC. USF Health and Paradigm Medical Communications, LLC accept no liability for the content referenced in this activity.

Privacy policy
Paradigm Medical Communications, LLC or hosted contracted partner is committed to protecting the privacy of those who participate in the activities located at www.paradigmmc.com (herein referred to as “website”). The information below describes the security of the website for safeguarding personal information and the rationale for collection and use of personal information.

Security/safeguarding personal information
This website has physical and procedural safeguards in place to prevent unauthorized access to personal information used to access this website.

Collection and use of your personal information
The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing the program. Required items include first name, last name, degree, and email address. These items are necessary. Participants are also required to complete an evaluation of the CME activity. All evaluative information submitted is collected and retained, and used by Paradigm Medical Communications, LLC to continuously improve the learning experience.

Paradigm Medical Communications, LLC does not transfer, sell, or share personal information with outside parties. Paradigm Medical Communications, LLC will not otherwise disclose personal information unless required to in a legal process. Paradigm Medical Communications, LLC staff members review individual test results to the extent necessary to record and track participants’ credits.
 

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If you have any questions or comments, please email us at contactus@paradigmmc.com.

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