Release Date: April 12, 2024 
Expiration Date: April 12, 2025
Time to Complete Activity: 1.75 hours

Faculty

James E. Galvin, MD, MPH
Alexandria and Bernard Schoninger Endowed Chair in Memory Disorders
Professor of Neurology, Psychiatry and Behavioral Sciences
Chief, Division of Cognitive Neurology
Director, Comprehensive Center for Brain Health
Director and Principal Investigator, Lewy Body Dementia Research Center of Excellence
Department of Neurology 
University of Miami Miller School of Medicine
Boca Raton, FL

Marwan Noel Sabbagh, MD, FAAN, FANA
Moreno Family Chair for Alzheimer’s Research
Vice Chairman for Research and Professor
Department of Neurology
Barrow Neurological Institute
Phoenix, AZ

Charles Vega, MD, FAAFP
Health Sciences Clinical Professor
UC Irvine Department of Family Medicine
Assistant Dean for Culture and Community Education
UC Irvine School of Medicine
Director, UC Irvine Program in Medical Education for the Latino Community (PRIME-LC)
Irvine, CA
 

Target Audience 

This activity has been designed to meet the educational needs of Alzheimer’s disease (AD) specialists (including neurologists, psychiatrists, and geriatricians) and primary care providers (PCPs) (including internists, family physicians, generalists, nurse practitioners, and PAs). It may also benefit other clinicians who are involved or interested in the management of patients with symptoms that could indicate AD.
 

Educational Provider 

This activity is provided by Paradigm Medical Communications, LLC.  
 

Supporter Acknowledgment 

This activity is supported by an educational grant from Eisai Inc.

Program Overview 

Managing the care of patients with AD is challenging for both PCPs and specialists. Available treatments have attempted to alleviate symptoms; however, a recently approved novel anti-amyloid therapy is the first to demonstrate a positive impact on both AD pathophysiology and disease progression—if applied early. Despite this groundbreaking advance, hurdles to implementing disease-modifying therapy remain, including diagnostic delays, use of biomarker assessments that establish treatment eligibility, and ongoing monitoring to detect potential adverse events. PCPs and specialists have unique roles in caring for this population, and are well positioned to identify and manage treatment-eligible patients appropriately.

Learning Objectives

Upon completion of this activity, participants should be able to:

All Audiences

• Describe the natural history of AD in relation to the potential for disease modification with novel therapy
• Outline key efficacy and safety data related to novel and emerging therapies that target early-stage AD

AD Specialists

• Confirm a diagnosis of AD based on appropriate use and interpretation of biomarker assessments
• Demonstrate appropriate use of anti-amyloid therapy in patients with early symptomatic AD, such as appropriate patient selection, ongoing monitoring, and management of adverse events

PCPs

• Recognize patients who would benefit from further evaluation/specialist referral for potential AD, based on signs, symptoms, and risk factors
• Identify key points for education and counseling of patients who may be eligible for, or are already receiving, disease-modifying therapy for early-stage AD

Physician Accreditation Statement

Paradigm Medical Communications, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
 

Physician Credit Designation Statement

Paradigm Medical Communications, LLC designates this enduring material for a maximum of 1.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

PA Continuing Education 

PAs may claim a maximum of 1.75 Category 1 credits for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society.

Nurse Practitioner Continuing Education 

The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.

Hardware/Software Requirements

This accredited CME activity is designed using HTML5 web components. As you navigate the video using the supplied controls, the slides will sync to the speaker.

Supported Browsers (Desktop/Mobile)
Chrome 45+, Firefox 40+, Edge, Edge Chromium, Safari 8+, Opera 31+

PDF documents
This activity may contain PDF documents. Most current browsers support viewing of PDFs natively, but you may also download a free version of Adobe Acrobat Reader here: http://get.adobe.com/reader

Technical Support
If you have any technical problems or playback issues, email us at contactus@paradigmmc.com.

Instructions for Participation

To receive a certificate of participation, participants must:

• Follow instructions to register or log in with your professional information and complete the preassessment
• View the online activity in its entirety
• Complete and submit the online postassessment and evaluation. You must answer 70% of the postassessment questions correctly to earn credit. You will have unlimited opportunities to successfully complete the postassessment

A certificate of participation will be available for download/printing immediately following your successful completion of the postassessment and evaluation.

For questions regarding CME credit, contact the Paradigm CME Department at cme@paradigmmc.com.

There are no fees for participating in this activity.

Disclosure of Relevant Financial Relationships

In accordance with the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education, Paradigm requires that all planners, faculty, and others who are in a position to control the content of this activity disclose all financial relationships with ineligible companies during the past 24 months.

All relevant relationships are identified and mitigated according to Paradigm policy prior to individuals assuming their roles, and are disclosed prior to learners’ engagement in the activity. Paradigm is committed to providing learners with high-quality accredited continuing education that promotes improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The content of this activity was independently reviewed to ensure that it is fair and balanced, scientifically rigorous, evidence based, and aligned with the public interest. All relevant relationships have been mitigated.

James E. Galvin, MD, MPH
Advisor: Biogen; Cognivue, Inc.; Eisai Inc.; Eli Lilly and Company; F. Hoffmann-La Roche AG; GE Healthcare; Genentech, Inc.

Marwan Noel Sabbagh, MD, FAAN, FANA
Consultant: Anavex Life Sciences Corp.; Cognito Therapeutics; Corium, LLC; Eisai Inc.; Eli Lilly and Company; F. Hoffmann-La Roche AG; KeifeRx; NeuroTherapia, Inc.; Novo Nordisk A/S; Prothena; Signant Health; Synaptogenix; T3D Therapeutics
Stocks: Alzheon; Athira Pharma, Inc.; Lighthouse Pharmaceuticals; NeuroReserve; NeuroTau; Optimal Cognitive Health Company; Reservoir Neuroscience; Seq Biomarque LLC; TransDermix; Versanum, Inc.; uMETHOD
Other (Board of Directors): EIP Pharma

Charles Vega, MD, FAAFP
Consultant: Boehringer Ingelheim International GmbH; GlaxoSmithKline

Paradigm Medical Communications, LLC staff members have no relevant financial relationships with ineligible companies to disclose.

Independent peer reviewer has no relevant financial relationships with ineligible companies to disclose.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not approved by the FDA.

Disclaimer

This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. Reasonable efforts have been taken to present educational subject matter in a balanced, unbiased fashion, and in compliance with regulatory requirements. However, each activity participant must always use his or her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

If included, signed statements of informed consent granting permission for publication have been obtained for all photographs and videos in which an individual can be identified.

As an ACCME-accredited provider, Paradigm Medical Communications, LLC must ensure that its activities include a balanced view of therapeutic options. Use of generic names contributes to this impartiality. The use of trade names should not be viewed as an endorsement of specific products by Paradigm Medical Communications, LLC.

Terms of Use and Privacy Policy
Disclaimer
The materials provided for this activity are for informational purposes only and should not be used for diagnosis or treatment of a health problem without consulting a licensed medical professional. This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. References to any entity, product, service, or source of information on this website should not be considered an endorsement, either direct or implied, by Paradigm Medical Communications, LLC. Paradigm Medical Communications, LLC accepts no liability for the content referenced in this activity.

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Security/safeguarding personal information
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Collection and use of your personal information
The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing the program. Required items include first name, last name, degree, and email address. These items are necessary. Participants are also required to complete an evaluation of the CME activity. All evaluative information submitted is collected and retained, and used by Paradigm Medical Communications, LLC to continuously improve the learning experience.

Paradigm Medical Communications, LLC does not transfer, sell, or share personal information with outside parties. Paradigm Medical Communications, LLC will not otherwise disclose personal information unless required to in a legal process. Paradigm Medical Communications, LLC staff members review individual test results to the extent necessary to record and track participants’ credits.

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