Release Date: January 29, 2021 
Last Reviewed: January 27, 2021
Expiration Date: January 29, 2022
Time to Complete Activity: 1.0 hour
*This activity expired for credit on January 29, 2022 and is no longer available for credit

Faculty 
Gregory Piazza, MD, MS
Director, Vascular Medicine Section
Division of Cardiovascular Medicine
Brigham and Women’s Hospital
Associate Professor of Medicine
Harvard Medical School
Boston, MA

Joshua A. Beckman, MD, MS
Professor of Medicine
Director, Vascular Medicine
Vanderbilt University Medical Center
Nashville, TN
This activity is provided by Paradigm Medical Communications, LLC.  

Disclosure of Commercial Support
This activity is supported by an educational grant from the Bristol-Myers Squibb and Pfizer Alliance.    

Target Audience
This activity has been designed to address the educational needs of venous thromboembolism (VTE) specialists, pulmonologists, hematologist/oncologists, vascular surgeons, emergency department physicians, internists, family medicine practitioners, allied healthcare professionals (HCPs), and other clinicians who are involved or interested in the management of patients with VTE.

Statement of Need
VTE is a common and potentially deadly vascular disease associated with a high rate of recurrence. Therefore, long-term anticoagulation treatment is often needed to prevent future events. Although randomized controlled trials (RCTs) have been instrumental in informing a shift toward preferential use of direct oral anticoagulants (DOACs) versus warfarin or low-molecular-weight heparin (LMWH) in many patients with VTE, the shortcomings of these trials (eg, lack of head-to-head comparisons and limitations in the number and type of patients studied) leave clinicians with little guidance on optimal treatment of the diverse patient subsets they encounter. Real-world evidence (RWE) studies can be instrumental in filling this void. This interactive DASHboard webinar will provide an overview of the methodology, quality, and key findings from recent RWE studies on this topic, along with case studies, to help the wide variety of clinicians involved in the care of patients with VTE interpret and apply these data to ensure safe, effective, and individualized treatment.

Learning Objectives
Upon completion of this activity, participants should be able to:

• Evaluate the benefits and limitations of high-quality RWE studies in the context of anticoagulation decision-making for patients with VTE 
• Select evidence-based treatment plans for VTE that demonstrate understanding of the real-world benefits and risks of DOACs, warfarin, and LMWH across a variety of patient types 

Agenda

• Assessment and Value of RWE
• VTE Management: Deciphering RWE, RCTs, and Guideline Recommendations
• Case Studies: Applying RWE to Clinical Practice 

Physician Accreditation Statement
Paradigm Medical Communications, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Physician Credit Designation Statement
Paradigm Medical Communications, LLC designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

PA Continuing Education
PAs may claim a maximum of 1.0 Category 1 credits for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society. 

Nurse Practitioner Continuing Education
The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.

Instructions for Participation 
To receive a CME certificate of participation, you should:

• Follow instructions to register or log in with your professional information and complete the preactivity assessment
• View the online activity in its entirety
• Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest

A certificate of participation will be available for download/printing immediately following your successful completion of the posttest and evaluation.

For questions regarding CME credit, contact the Paradigm CME Department at (845) 398-5949 or cme@paradigmmc.com.

There is no fee required for participation in this activity.

Hardware/Software Requirements
This certified CME activity is designed using HTML5 web components. As you navigate the video using the supplied controls, the slides will sync to the speaker.

Supported Browsers (Desktop/Mobile)
Chrome 45+, Firefox 40+, Edge, Edge Chromium, Safari 8+, Opera 31+

PDF documents
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Technical Support: If you have any technical problems or playback issues email us at contactus@paradigmmc.com.

Disclosures
In accordance with ACCME requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in the activity. These relationships are described below. Any potential conflicts of interest have been resolved.

Faculty 
Gregory Piazza, MD, MS
Salary: Boston Scientific Corporation (spouse)
Consulting Fees: Agile Therapeutics; Amgen Inc
Grant/Research Support: Bayer HealthCare; Boston Scientific; Bristol-Myers Squibb Company and Pfizer Alliance; Janssen Pharmaceuticals, Inc; Portola Pharmaceuticals, Inc

Joshua A. Beckman, MD 
Consulting fees: Amgen Inc; Bayer Corporation; Janssen Pharmaceuticals, Inc; JanOne
Grant/Research support: Novartis
Stockholder: EMX Royalty Corp; Jana Care Inc. 

Paradigm Medical Communications, LLC staff members have no financial relationships to disclose.

Independent peer reviewer has no financial relationships to disclose. 

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Paradigm Medical Communications, LLC has implemented a system to resolve conflicts of interest for each CME activity to help ensure content is objective, fair and balanced, independent, and aligned with the public interest. Conflicts, if any, are resolved through one or more processes. All CME content in this activity has been independently reviewed to ensure that it is free of commercial bias, scientifically rigorous, aligned with the public interest, and compliant with all regulatory guidance and the ACCME’s Standards for Commercial Support of Continuing Medical Education.

Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not approved by the FDA.

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