Roundtable: ADCs Targeting HER2 in NSCLC

Release Date: May 2, 2025
Expiration Date: May 2, 2026
Time to Complete Activity: 30 minutes

Faculty

Jhanelle Gray, MD—Chairperson
Professor
University of South Florida 
Morsani College of Medicine
Chair, Department of Thoracic Oncology
Program Lead, Thoracic Oncology
Program Co-Leader, Molecular Medicine
Moffit Cancer Center
Tampa, FL

Deborah Doroshow, MD, PhD 
Associate Professor of Medicine
Icahn School of Medicine at Mount Sinai 
New York, NY

Helena A. Yu, MD
Research Director, Thoracic Oncology Service
Associate Attending 
Memorial Sloan Kettering Cancer Center
New York, NY
 

Target Audience 

This activity has been designed to address the educational needs of medical oncologists, pathologists, advanced oncology certified nurse practitioners, oncology PAs, oncology nurses, oncology pharmacists, fellows, and residents and may be of interest to pathologists and other healthcare providers who manage patients with non-small cell lung cancer (NSCLC).
 

Educational Provider

This activity is provided by USF Health in partnership with Paradigm Medical Communications, LLC and Moffitt Cancer Center.

 

Supporter Acknowledgment 

This activity is funded by independent medical education grants from Daiichi Sankyo, Inc and AstraZeneca.
 

Program Overview

Despite advancements in NSCLC treatment, patients with human epidermal growth factor receptor 2 (HER2) overexpression face unique challenges in care. Although a new indication of an antibody-drug conjugate (ADC) that targets HER2 means clinicians now have more treatment options for patients with NSCLC, testing for HER2 as an actionable biomarker is still challenging. This activity will explore HER2 overexpression, testing, and the latest efficacy and safety data for HER2-targeted ADCs. Clinicians will gain practical insights to optimize treatment selection and align care with current guidelines, ultimately improving patient outcomes.
 

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Assess the most recent data supporting the role of HER2 overexpression as an actionable biomarker in NSCLC 
  • Apply the latest clinical data regarding HER2-targeting agents to treatment decisions for patients with NSCLC
  • Review safety and efficacy clinical trial data of HER2-targeted agents

Accreditations

Physicians

USF Health is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

USF Health designates this enduring activity for a maximum of 0.50 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The European Union of Medical Specialists (UEMS)–European Accreditation Council for Continuing Medical Education (EACCME) has an agreement of mutual recognition of continuing medical education (CME) credit with the American Medical Association (AMA). European physicians interested in converting AMA PRA Category 1 CreditTM into European CME credit (ECMEC) should contact the UEMS (www.uems.eu).
 

Advanced Practice Providers

Physician Assistants may claim a maximum of 0.50 Category 1 credit for completing this activity. NCCPA accepts AMA PRA Category 1 CreditTM from organizations accredited by ACCME or a recognized state medical society.

The AANPCP accepts certificates of participation for educational activities approved for AMA PRA Category 1 CreditTM by ACCME-accredited providers. APRNs who participate will receive a certificate of completion commensurate with the extent of their participation.
 

Nurses

USF Health is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.

A maximum of 0.50 contact hour may be earned by learners who successfully complete this continuing nursing education activity. USF Health, the accredited provider, acknowledges Paradigm Medical Communications, LLC as the partner in the planning and execution of this CNE activity.

This activity is awarded 0.5 ANCC pharmacotherapeutic contact hour.
 

Pharmacists

USF Health is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. This knowledge-based program has been approved for 0.5 contact hour (0.05 CEU). Universal program number is as follows: 0230-9999-25-009-H01-P

Date of original release: May 2, 2025. Date credit expires: May 2, 2026.
 

Hardware/Software Requirements

This accredited CME activity is designed using HTML5 web components. As you navigate the video using the supplied controls, the slides will sync to the speaker.

Supported Browsers (Desktop/Mobile)
Chrome 45+, Firefox 40+, Edge, Edge Chromium, Safari 8+, Opera 31+

PDF documents
This activity may contain PDF documents. Most current browsers support viewing of PDFs natively, but you may also download a free version of Adobe Acrobat Reader here: http://get.adobe.com/reader

Technical Support
If you have any technical problems or playback issues, email us at contactus@paradigmmc.com.
 

Instructions for Participation

To receive a certificate of participation, participants must:

  • Follow instructions to register or log in with your professional information and complete the pretest
  • View the online activity in its entirety
  • Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest

A certificate of participation will be available for download/printing immediately following your successful completion of the posttest and evaluation.

For questions regarding CME credit, please contact cpdsupport@usf.edu.

There are no fees for participating in this activity.
 

Disclosure of Relevant Financial Relationships

USF Health adheres to the Accreditation Council for Continuing Medical Education’s (ACCME) Standards for Integrity and Independence in Accredited Continuing Education. All individuals in a position to influence content have disclosed to USF Health any financial relationship with an ineligible organization. USF Health has reviewed and mitigated all relevant financial relationships related to the content of the activity. The relevant financial relationships are listed below.

Faculty 
Deborah Doroshow, MD, PhD 
Advisory board or panel fees: AstraZeneca; Boehringer Ingelheim; Bristol Myers Squibb; Eli Lilly; EMD Serono/Merck KGaA; Genentech; Gilead Sciences; Merck & Co.; Novartis; Panbela Therapeutics; Pfizer; Regeneron

Jhanelle Gray, MD
Advisory board or panel fees: Blueprint Medicines; Catalyst Pharmaceuticals; Coherus; Daiichi Sankyo; Eli Lilly; EMD Serono/Merck KGaA; Janssen Scientific Affairs; Jazz Pharmaceuticals; Novartis; Pfizer; Regeneron; Spectrum Pharmaceuticals (ODAC); Takeda Pharmaceuticals; Triptych Health Partners; Zai Lab
Consultant: AstraZeneca; Blueprint Medicines; Catalyst Pharmaceuticals; Coherus; Daiichi Sankyo; Eli Lilly; EMD Serono/Merck KGaA; Janssen Scientific Affairs; Jazz Pharmaceuticals; Merck & Co.; Novartis; Pfizer; Regeneron; Spectrum Pharmaceuticals (ODAC); Takeda Pharmaceuticals; Triptych Health Partners; Zai Lab
Grants/research support: AstraZeneca; Boehringer Ingelheim; Bristol Myers Squibb; Eli Lilly; EMD Serono/Merck KGaA; Genentech; Gilead Sciences; Merck & Co.; Novartis; Panbela Therapeutics; Pfizer; Regeneron

Helena A. Yu, MD:
Consultant: AbbVie; Amgen; AstraZeneca; Bristol Myers Squibb; Cullinan Therapeutics; Daiichi Sankyo; Janssen; Pfizer; Taiho; Takeda
Grants/research support: AstraZeneca; Cullinan Therapeutics; Daiichi Sankyo; Janssen; Kumquat Biosciences; SystImmune; Taiho

Content Reviewers
Danielle Walker DNP, APRN, AGNP-C has no financial interests/relationships or affiliations in relation to this activity.
Christy Thai PharmD, BCPS has no financial interests/relationships or affiliations in relation to this activity.

Staff
USF Health Office of Continuing Professional Development and Paradigm Medical Communications, LLC staff have no relevant financial interests/relationships or affiliations in relation to this activity.

The information provided by this CE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

USF is an Equal Opportunity/Affirmative Action/Equal Access Institution.

USF Health is accredited by the Accreditation Council for Continuing Medical Education, the American Nurses Credentialing Center, and the Accreditation Council for Pharmacy Education to provide continuing education to healthcare professionals. As an accredited provider, USF Health is required to disclose personal information to relevant accredited bodies that certify CE to process credits/contact hours, comply with reporting requirements, and for internal recordkeeping and regulatory purposes. USF Health does not share or sell any individual’s contact information or unique identifiers to any commercial supporter, advertiser, or third party without the specific permission of the individual.
 

Disclaimer

This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, USF Health and Paradigm Medical Communications, LLC. Reasonable efforts have been taken to present educational subject matter in a balanced, unbiased fashion, and in compliance with regulatory requirements. However, each activity participant must always use his or her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

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Disclaimer
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The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing the program. Required items include first name, last name, degree, and email address. These items are necessary. Participants are also required to complete an evaluation of the CME activity. All evaluative information submitted is collected and retained, and used by Paradigm Medical Communications, LLC to continuously improve the learning experience.

Paradigm Medical Communications, LLC does not transfer, sell, or share personal information with outside parties. Paradigm Medical Communications, LLC will not otherwise disclose personal information unless required to in a legal process. Paradigm Medical Communications, LLC staff members review individual test results to the extent necessary to record and track participants’ credits.
 

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