Release Date: August 31, 2026
Expiration Date: August 31, 2027
Time to Complete Activity: 15 minutes 

Faculty

Nicole Lamanna, MD 
Judy Horrigan Professor of Medicine, Leukemia Service
Director, Chronic Lymphocytic Leukemia Program
Hematologic Malignancies Section
Herbert Irving Comprehensive Cancer Center
New York-Presbyterian/Columbia University Medical Center
New York, NY
 

Target Audience 

This activity has been designed to address the educational needs of chronic lymphocytic leukemia (CLL) specialists (academic medical center) and community-based oncologists, including hematologist/oncologists, who diagnose, treat, and manage patients with CLL.
 

Educational Provider

This activity is provided by Paradigm Medical Communications, LLC.  
 

Collaborating Partners

This activity is part of a larger educational initiative developed in collaboration with Albert Einstein College of Medicine–Montefiore Medical Center, CLL Society, HealthTree Foundation, Moffitt Cancer Center, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, The University of Texas MD Anderson Cancer Center, and USF Health.

 

Supporter Acknowledgment 

This activity is supported by an educational grant from AbbVie Inc.
 

Program Overview 

This interactive quiz-and-learn activity reviews contemporary approaches to the management of CLL, including evidence-based treatment selection influenced by current clinical trial data and practice guidelines, and considerations for continuous and fixed-duration therapy. This survey-based activity also examines the benefits and limitations of available treatment approaches and highlights the importance of shared decision-making (SDM) to ensure treatment plans align with patients’ goals, preferences, and clinical needs.
 

Learning Objectives

Upon completion of this activity, participants should be able to:

• Discuss appropriate treatment options for patients with CLL based on evidence-based guidelines and clinical trial data
• Examine the pros and cons of continuous therapy and fixed-duration therapy for CLL
• Outline the value of SDM when developing a treatment plan for patients with CLL

Physician Accreditation Statement

Paradigm Medical Communications, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
 

Physician Credit Designation Statement

Paradigm Medical Communications, LLC designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
 

PA Continuing Education 

PAs may claim a maximum of 0.25 Category 1 credits for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society.
 

Nurse Practitioner Continuing Education 

The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.
 

Hardware/Software Requirements

This accredited CME activity is designed using HTML5 web components. As you navigate the video using the supplied controls, the slides will sync to the speaker.
Supported Browsers (Desktop/Mobile)
Chrome 45+, Firefox 40+, Edge, Edge Chromium, Safari 8+, Opera 31+

PDF documents
This activity may contain PDF documents. Most current browsers support viewing of PDFs natively, but you may also download a free version of Adobe Acrobat Reader here: http://get.adobe.com/reader

Technical Support: If you have any technical problems or playback issues, email us at contactus@paradigmmc.com.
 

Instructions for Participation

To receive a certificate and claim credit, participants must:

• Follow instructions to register or log in with your professional information and complete the preactivity evaluation
• View the online activity in its entirety
• Complete and submit the online evaluation

A certificate of participation will be available for download/printing immediately following your successful completion of the posttest and evaluation.

For questions regarding CME credit, contact the Paradigm CME Department at cme@paradigmmc.com.

There are no fees for participating in this activity.
 

Disclosure of Relevant Financial Relationships

In accordance with the Accreditation Council for Continuing Medical Education’s (ACCME) Standards for Integrity and Independence in Accredited Continuing Education, Paradigm requires that all planners, faculty, and others who are in a position to control the content of this activity disclose all financial relationships with ineligible companies during the past 24 months.

All relevant relationships are identified and mitigated according to Paradigm policy prior to individuals assuming their roles and are disclosed prior to learners’ engagement in the activity. Paradigm is committed to providing learners with high-quality accredited continuing education that promotes improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The content of this activity was independently reviewed to ensure that it is fair and balanced, scientifically rigorous, evidence based, and aligned with the public interest. All relevant relationships have been mitigated.

Faculty 
Nicole Lamanna, MD 
Advisor: AbbVie Inc.; AstraZeneca; BeOne Medicines; Eli Lilly and Company; Genentech, Inc.; Genmab A/S; Octapharma USA, Inc. 
Consultant: AbbVie Inc.; AstraZeneca; BeOne Medicines; Eli Lilly and Company; Genentech, Inc.; Genmab A/S; Octapharma USA, Inc. 
Research Funding: AbbVie Inc.; AstraZeneca; BeOne Medicines; Eli Lilly and Company; Genentech, Inc.; Genmab A/S; Octapharma USA, Inc.; Octernal Therapeutics

CLL Society Reviewer 
Brian Koffman, MD
Consultant: AbbVie Inc.; BeOne Medicines; Biomea Fusion Inc.; Bristol-Myers Squibb Company; Eli Lilly and Company; Johnson & Johnson Services, Inc; Nurix Therapeutics, Inc.
Independent Contractor: AbbVie Inc.; AstraZeneca; BeOne Medicines; Bristol-Myers Squibb Company; Eli Lilly and Company; Johnson & Johnson Services, Inc; Nurix Therapeutics, Inc.
Stocks: AbbVie Inc.; AstraZeneca; Biomea Fusion Inc.; Bristol-Myers Squibb Company; Johnson & Johnson Services, Inc; Merck & Co, Inc; Nurix Therapeutics, Inc.; Pfizer Inc; Vincerx Pharma, Inc.

Paradigm Medical Communications, LLC, Albert Einstein College of Medicine–Montefiore Medical Center, HealthTree Foundation, Moffitt Cancer Center, Northwestern University Lurie Cancer Center, The University of Texas MD Anderson Cancer Center and USF Health staff members have no relevant financial relationships with ineligible companies to disclose. 

Independent peer reviewer has no relevant financial relationships with ineligible companies to disclose.
 

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not approved by the FDA.
 

Disclaimer

This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. Reasonable efforts have been taken to present educational subject matter in a balanced, unbiased fashion, and in compliance with regulatory requirements. However, each activity participant must always use his or her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

If included, signed statements of informed consent granting permission for publication have been obtained for all photographs and videos in which an individual can be identified.

As an ACCME-accredited provider, Paradigm Medical Communications, LLC must ensure that its activities include a balanced view of therapeutic options. Use of generic names contributes to this impartiality. The use of trade names should not be viewed as an endorsement of specific products by Paradigm Medical Communications, LLC.

Terms of Use and Privacy Policy
Disclaimer
The materials provided for this activity are for informational purposes only and should not be used for diagnosis or treatment of a health problem without consulting a licensed medical professional. This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. References to any entity, product, service, or source of information on this website should not be considered an endorsement, either direct or implied, by Paradigm Medical Communications, LLC. Paradigm Medical Communications, LLC accepts no liability for the content referenced in this activity.

Privacy policy
Paradigm Medical Communications, LLC or hosted contracted partner is committed to protecting the privacy of those who participate in the activities located at www.paradigmmc.com (herein referred to as “website”). The information below describes the security of the website for safeguarding personal information and the rationale for collection and use of personal information.

Security/safeguarding personal information
This website has physical and procedural safeguards in place to prevent unauthorized access to personal information used to access this website.

Collection and use of your personal information
The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing the program and may be used to track registration and participation. Required items include first name, last name, degree, and email address. These items are necessary. Participants are also required to complete an evaluation of the CME activity. All evaluative information submitted is collected and retained, and used by Paradigm Medical Communications, LLC to continuously improve the learning experience.

Paradigm Medical Communications, LLC does not otherwise transfer, sell, or share personal information with outside parties. Paradigm Medical Communications, LLC will not otherwise disclose personal information unless required to in a legal process. Paradigm Medical Communications, LLC staff members review individual test results to the extent necessary to record and track participants’ credits.
 

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If you have any questions or comments, please email us at contactus@paradigmmc.com.

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