JAK/TYK2 Inhibition: New Frontiers in the Treatment of Psoriasis
JAK/TYK2 Inhibition: New Frontiers in the Treatment of Psoriasis
Release Date: December 16, 2020
Last Reviewed: December 15, 2020
Expiration Date: December 16, 2021
Time to Complete Activity: 1 hour
*This activity expired for credit on December 16, 2021 and is no longer available for credit
April W. Armstrong, MD, MPH
Associate Dean, Clinical Research
Professor of Dermatology
Director, Clinical Research Support, Southern California CTSI
Keck School of Medicine
University of Southern California
Los Angeles, CA
Seemal R. Desai, MD, FAAD
Clinical Assistant Professor
Department of Dermatology
University of Texas Southwestern Medical Center
Gary Goldenberg, MD
Assistant Clinical Professor, Dermatology
Mount Sinai School of Medicine
New York, NY
This activity is provided by the University of Cincinnati.
Paradigm Medical Communications, LLC is the educational partner.
Disclosure of Commercial Support
This activity is supported by an educational grant from Bristol-Myers Squibb.
This activity has been designed to address the educational needs of dermatology clinicians. It may also be of benefit to rheumatology and primary care clinicians, as well as other healthcare providers involved with or interested in the management of patients with psoriasis.
Statement of Need
Psoriasis is a common autoimmune disorder with associated comorbidities that are more than skin deep. Patients with psoriasis are at increased risk for cardiovascular and metabolic disease, malignancies, and anxiety/depression. This activity will provide clinicians with a solid foundation for understanding the pathophysiology of psoriasis along with other autoimmune diseases, how this pathophysiology informs treatment options, and the most recent clinical trial data for current and emerging agents and management recommendations available to guide therapy selection.
Upon proper completion of this activity, participants should be better able to:
- Identify the JAK/TYK2-STAT–mediated pathways involved in the pathophysiology of psoriasis
- Summarize evidence for the efficacy, safety, and mechanisms of action for new and emerging agents in psoriasis, and the implications for treatment
- Apply current research findings and recommendations to the treatment of psoriasis and comorbidities
- Pathophysiology of Psoriasis
- JAK/TYK2 Inhibitors in Psoriasis Data
- Psoriasis Treatment Guidelines
- New Directions in Psoriasis Therapy: The Role of Emerging JAK/TYK2 Inhibitors in Psoriasis
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The University of Cincinnati designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
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In accordance with ACCME requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in the activity. These relationships are described below.
April W. Armstrong, MD MPH
Consulting Fees: AbbVie Inc.; Bristol-Meyers Squibb Company; Dermavant Sciences, Inc.; Eli Lilly and Company; Janssen Pharmaceuticals, Inc; LEO Pharma Inc.; Modernizing Medicine; Novartis; Ortho Dermatologics; Pfizer Inc; Regeneron Pharmaceuticals, Inc; Sanofi Genzyme; Sun Pharmaceutical Industries Ltd
Grant/Research Support: AbbVie Inc.; Bristol-Meyers Squibb Company; Dermavant Sciences, Inc.; Dermira, Inc.;
Eli Lilly and Company; Janssen Pharmaceuticals, Inc; Kyowa Kirin Pharmaceutical Research, Inc.; LEO Pharma Inc.; Novartis; Regeneron Pharmaceuticals Inc; Sanofi Genzyme; UCB, Inc.
Seemal R. Desai, MD, FAAD
Consulting Fees: Bristol-Myers Squibb Company; Pfizer Inc
Speakers Bureau: Pfizer Inc
Gary Goldenberg, MD
Consulting Fees: AbbVie Inc.; Eli Lilly and Company; Pfizer Inc
Speakers Bureau: AbbVie Inc.; Eli Lilly and Company; Pfizer Inc
University of Cincinnati staff members and reviewers have no financial relationships to disclose.
Paradigm Medical Communications, LLC staff members have no financial relationships to disclose.
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