Quelling the COVID-19 Cytokine Storm in Hospitalized Patients: Current Thinking, Emerging Data



Release Date: December 17, 2021 
Expiration Date: December 17, 2022
Time to Complete Activity1.0 hour

Faculty
Leonard Calabrese, DO
Professor of Medicine
Director, RJ Fasenmyer Centre for Clinical Immunology 
Vice Chair, Department of Rheumatic and Immunologic Disease 
Co-Director, Centre for Vasculitis Care and Research
Cleveland Clinic Lerner College of Medicine 
Case Western Reserve University 
Cleveland, OH

Leslie Tolle, MD
Assistant Professor of Medicine 
Cleveland Clinic Lerner College of Medicine 
Case Western Reserve University
Interim Director, Section of Diffuse Parenchymal Lung Disease
Respiratory Institute, Cleveland Clinic
Cleveland, OH

This activity is provided by Paradigm Medical Communications, LLC.  

Disclosure of Financial Support
This activity is supported by an educational grant from Genentech, a member of the Roche Group.    

Target Audience
This activity has been designed for a range of clinicians who are integral in managing patients with severe COVID-19 throughout hospitalization (critical care specialists, infectious disease specialists, emergency medicine physicians, pulmonologists, hospitalists, and primary care clinicians). The activity may be of benefit to other clinicians involved in the treatment of hospitalized patients with severe COVID-19 who often have little experience with immunomodulatory treatment. 

Statement of Need
The search for optimal COVID-19 treatment remains an urgent priority, especially in hospitalized patients who are at the highest risk for mortality and other negative outcomes. An appreciation of the “cytokine storm” in severe COVID-19 has illuminated a role for interleukin-6 (IL-6) inhibition using tocilizumab, an IL-6 receptor blocker, or Janus kinase (JAK) inhibition in certain patients. Continually emerging data, evolving guideline recommendations, and confusion about patient selection and the optimal timing of treatment initiation challenge hospital-based clinicians to keep pace and make appropriate, evidence-based care decisions. This webinar reviews current thinking on the role of recommended immunomodulatory therapies and agents in late-phase investigation, including the pathophysiological processes they target, contextualization of clinical trial data discussed and illustrated in whiteboard animations, and with expert-led discussion to help clinicians make individualized COVID treatment decisions in the hospital.

Learning Objectives
Upon completion of this activity, participants should be able to:

  • Identify key characteristics of COVID-19 pathophysiology that are associated with more progressive and severe disease
  • Summarize efficacy and safety of treatments that are recommended to treat hospitalized patients with severe COVID-19
  • Make immunomodulatory treatment decisions (eg, agent selection and timing of initiation) for hospitalized patients with severe COVID-19 based on clinical characteristics and current data
Agenda
  • COVID Acute Respiratory Distress Syndrome (ARDS) Case
  • A “Rheum” With a View: The Cytokine Storm in Severe COVID-19
    • Whiteboard: Pathophysiology of the Immune Response to COVID Infection
    • Whiteboard: Development and Management of the Hyperimmune Response to COVID Infection
    • Whiteboard: Current Treatment of Hospitalized Patients With COVID Infection
  • COVID ARDS Treatment
  • COVID ARDS Case (Resumed)
 

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  • View the online activity in its entirety
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Disclosures
In accordance with ACCME requirements on disclosure, faculty and contributors are asked to disclose any financial relationships occurring over the past 24 months with ineligible companies whose products or services are associated with the area of medicine featured in the activity. These relationships are described below. Any potential conflicts of interest have been mitigated.

Leonard Calabrese, DO
Consultant: Genentech, Inc.; GlaxoSmithKline

Leslie B. Tolle, MD
Speakers Bureau: Boehringer Ingelheim Pharmaceuticals, Inc; Genentech, Inc. (expired 12/20)

Paradigm Medical Communications, LLC staff members have no financial relationships to disclose.

Independent peer reviewer has no financial relationships to disclose.

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