Release Date: December 11, 2023
Expiration Date: December 11, 2024
Time to Complete Activity: 0.5 hour

Faculty 

Rebecca Heist, MD, MPH
Associate Professor of Medicine
Harvard Medical School
Lee Albright and Nile Albright MD Endowed Chair in Clinical Cancer Research
Massachusetts General Hospital Cancer Center
Boston, MA

Alex Spira, MD, PhD, FACP
CEO and Clinical Director
NEXT Oncology-Virginia
Chair, Research Executive Committee
Co-Chair, Thoracic Committee
US Oncology Research
Co-Director
Virginia Cancer Specialists Research Institute
Fairfax, VA

Target Audience 

This activity has been designed to address the educational needs of oncology clinicians including physicians, nurse practitioners, and PAs who manage patients with lung cancer. It may also be of benefit to other healthcare professionals who have an interest in the topic.

Educational Provider 

This activity is provided by Paradigm Medical Communications, LLC.  

In collaboration with the American Lung Association. 

Supporter Acknowledgment 

This activity is supported by educational grants from AstraZeneca Pharmaceuticals and Daiichi Sankyo, Inc.

Program Overview 

The development of antibody-drugs conjugates (ADCs) that target tumor-associated calcium signal transducer 2 (TROP2) has the potential to change the treatment paradigm for patients with advanced non-small cell lung cancer (NSCLC), including those with or without actionable genomic alterations. This educational activity will provide a better understanding of the role of TROP2 in NSCLC, the mechanism of action of TROP2-targeted ADCs, and how the latest data—and ongoing phase 3 trials—will help inform the potential use of these agents in patient care.

Learning Objectives

Upon completion of this activity, participants should be able to:

• Discuss the biology of TROP2 in NSCLC and the mechanisms of action of TROP2-directed ADCs
• Assess current data on TROP2-directed ADCs, including patients with and without actionable genomic alterations, as well as key ongoing phase 3 trials
• Describe the safety profile of TROP2-directed ADCs, including adverse events of special interest (eg, interstitial lung disease)

Physician Accreditation Statement

Paradigm Medical Communications, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Physician Credit Designation Statement

Paradigm Medical Communications, LLC designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

PA Continuing Education 

PAs may claim a maximum of 0.50 Category 1 credit for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society.

Nurse Practitioner Continuing Education 

The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.

Hardware/Software Requirements

This accredited CME activity is designed using HTML5 web components. As you navigate the video using the supplied controls, the slides will sync to the speaker.

Supported Browsers (Desktop/Mobile)

Chrome 45+, Firefox 40+, Edge, Edge Chromium, Safari 8+, Opera 31+

PDF documents

This activity may contain PDF documents. Most current browsers support viewing of PDFs natively, but you may also download a free version of Adobe Acrobat Reader here: http://get.adobe.com/reader

Technical Support

If you have any technical problems or playback issues, email us at contactus@paradigmmc.com.

Instructions for Participation

To receive a certificate of participation, participants must:

• Follow instructions to register or log in with your professional information and complete the preassessment
• View the online activity in its entirety
• Complete and submit the online postassessment and evaluation. You must answer 70% of the postassessment questions correctly to earn credit. You will have unlimited opportunities to successfully complete the postassessment

A certificate of participation will be available for download/printing immediately following your successful completion of the postassessment and evaluation.

For questions regarding CME credit, contact the Paradigm CME Department at cme@paradigmmc.com.

There are no fees for participating in this activity.

Disclosure of Relevant Financial Relationships

In accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education, Paradigm requires that all planners, faculty, and others who are in a position to control the content of this activity disclose all financial relationships with ineligible companies during the past 24 months.

All relevant relationships are identified and mitigated according to Paradigm policy prior to individuals assuming their roles, and are disclosed prior to learners’ engagement in the activity. Paradigm is committed to providing learners with high-quality accredited continuing education that promotes improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The content of this activity was independently reviewed to ensure that it is fair and balanced, scientifically rigorous, evidence based, and aligned with the public interest. All relevant relationships have been mitigated. 

Faculty 
Rebecca Heist, MD, MPH
Consultant: AbbVie Inc.; AstraZeneca; Claim Therapeutics; Daiichi Sankyo Company, Limited; Eli Lilly and Company; Novartis AG; Regeneron Pharmaceuticals Inc; Sanofi
Research Funding: AbbVie Inc.; Agios Pharmaceuticals, Inc.; Corvus Pharmaceuticals; Daiichi Sankyo Company, Limited; Eli Lilly and Company; Erasca; Exelixis, Inc.; Mirati Therapeutics, Inc.; Novartis AG; Turning Point Therapeutics, Inc. (all funds paid to Harvard)

Alex Spira, MD, PhD, FACP 
Advisor: Amgen Inc; Array BioPharma, Inc.; AstraZeneca; Black Diamond Therapeutics; Blueprint Medicines Corporation; Bristol-Myers Squibb Company; Daiichi Sankyo Company, Limited; Eli Lilly and Company; Gritstone bio; InCyte; Janssen Pharmaceuticals, Inc; Jazz Pharmaceuticals; Merck & Co, Inc; Mersana Therapeutics Inc.; Mirati Therapeutics Inc; Novartis AG; Regeneron Pharmaceuticals Inc; Sanofi; Takeda Pharmaceutical Company Ltd
Research Funding: AbbVie Inc.; ADC Thereapeutics; Alkermes; Amgen Inc; ArriVent Biopharma; Astellas Pharma Inc.; Astex Pharmaceuticals; AstraZeneca; Black Diamond Therapeutics; Blueprint Medicines Corporation; Boehringer Ingelheim International GmbH; Bristol-Myers Squibb Company; CytomX Therapeutics; Daiichi Sankyo Company, Limited; F. Hoffmann-La Roche AG; Gritstone bio; InCyte; Ignyta, Inc.; Janssen Pharmaceuticals, Inc; LAM Therapeutics, Inc.; Loxo Oncology; MacroGenics, Inc.; Medikine; Mersana Therapeutics Inc.; Mirati Therapeutics Inc; NALO Therapeutics; Novartis AG; Regeneron Pharmaceuticals Inc; Revolution Medicines, Inc.; Rubius Therapeutics; Scorpion Therapeutics, Inc.; Synthekine; Takeda Pharmaceutical Company Ltd
Stocks: Eli Lilly and Company
Executive Role: NEXT Oncology Virginia
Honoraria: Amgen Inc; AstraZeneca; Bayer Corporation; Bristol-Myers Squibb Company; CytomX Therapeutics; Janssen Pharmaceuticals, Inc; Merck & Co, Inc; Novartis AG; Takeda Pharmaceutical Company Ltd

Paradigm Medical Communications, LLC staff members have no relevant financial relationships with ineligible companies to disclose.

The Lung Association staff members have no relevant financial relationships with ineligible companies to disclose. 

Independent peer reviewer has no relevant financial relationships with ineligible companies to disclose.
 

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not approved by the FDA.

Disclaimer

This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. Reasonable efforts have been taken to present educational subject matter in a balanced, unbiased fashion, and in compliance with regulatory requirements. However, each activity participant must always use his or her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

If included, signed statements of informed consent granting permission for publication have been obtained for all photographs and videos in which an individual can be identified.

As an ACCME-accredited provider, Paradigm Medical Communications, LLC must ensure that its activities include a balanced view of therapeutic options. Use of generic names contributes to this impartiality. The use of trade names should not be viewed as an endorsement of specific products by Paradigm Medical Communications, LLC. 

Terms of Use and Privacy Policy
Disclaimer
The materials provided for this activity are for informational purposes only and should not be used for diagnosis or treatment of a health problem without consulting a licensed medical professional. This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. References to any entity, product, service, or source of information on this website should not be considered an endorsement, either direct or implied, by Paradigm Medical Communications, LLC. Paradigm Medical Communications, LLC accepts no liability for the content referenced in this activity.

Privacy policy
Paradigm Medical Communications, LLC or hosted contracted partner is committed to protecting the privacy of those who participate in the activities located at www.paradigmmc.com (herein referred to as “website”). The information below describes the security of the website for safeguarding personal information and the rationale for collection and use of personal information.

Security/safeguarding personal information
This website has physical and procedural safeguards in place to prevent unauthorized access to personal information used to access this website.

Collection and use of your personal information
The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing the program. Required items include first name, last name, degree, and email address. These items are necessary. Participants are also required to complete an evaluation of the CME activity. All evaluative information submitted is collected and retained, and used by Paradigm Medical Communications, LLC to continuously improve the learning experience.

Paradigm Medical Communications, LLC does not transfer, sell, or share personal information with outside parties. Paradigm Medical Communications, LLC will not otherwise disclose personal information unless required to in a legal process. Paradigm Medical Communications, LLC staff members review individual test results to the extent necessary to record and track participants’ credits.

Contact Us

If you have any questions or comments, please email us at contactus@paradigmmc.com. 

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