Release Date: July 31, 2024
Expiration Date: July 31, 2025
Time to Complete Activity: 0.5 hour

Faculty 

April W. Armstrong, MD, MPH
Professor and Chief of Dermatology
University of California Los Angeles
Los Angeles, CA

Amit Garg, MD
Professor and Founding Chair
Department of Dermatology
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
Professor, Center for Health Innovations and Outcomes Research
Feinstein Institutes for Medical Research
Hempstead, NY

Mio Nakamura, MD, MS
Assistant Professor
Dermatology
University of Michigan
Ann Arbor, MI

Target Audience 

This activity has been designed to address the educational needs of dermatologists, dermatology nurse practitioners, and PAs. It may also be of benefit to primary care clinicians, rheumatologists, and other healthcare practitioners who are interested in the treatment of psoriasis.

Educational Provider 

This activity is provided by Paradigm Medical Communications, LLC.  
In collaboration with GRAPPA.  

Supporter Acknowledgment 

This activity is supported by an educational grant from Bristol Myers Squibb Company.

Program Overview 

In this edition of Psoriasis Prime Time, the faculty reviews the use of allosteric tyrosine kinase 2 (TYK2) inhibitors in the treatment of hard-to-treat psoriasis, including the rationale for TYK2 inhibition and clinical data associated with TYK2 inhibitors in psoriasis and emerging data in psoriatic arthritis (PsA). In addition, screening for PsA and use of systemic treatments to reduce joint symptoms are discussed.

Learning Objectives

Upon completion of this activity, participants should be able to:

• Describe how allosteric inhibition of TYK2 confers efficacy and safety in psoriasis
• Outline the safety, efficacy, and role of TYK2 inhibition in psoriatic disease management
• Devise patient-centric, evidence-based treatment plans for patients with psoriasis

Physician Accreditation Statement

Paradigm Medical Communications, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
 

Physician Credit Designation Statement

Paradigm Medical Communications, LLC designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

PA Continuing Education 

PAs may claim a maximum of 0.5 Category 1 credit for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society.

Nurse Practitioner Continuing Education 

The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.

Hardware/Software Requirements

This accredited CME activity is designed using HTML5 web components. As you navigate the video using the supplied controls, the slides will sync to the speaker.

Supported Browsers (Desktop/Mobile)
Chrome 45+, Firefox 40+, Edge, Edge Chromium, Safari 8+, Opera 31+

PDF documents
This activity may contain PDF documents. Most current browsers support viewing of PDFs natively, but you may also download a free version of Adobe Acrobat Reader here: http://get.adobe.com/reader

Technical Support
If you have any technical problems or playback issues, email us at contactus@paradigmmc.com.

Instructions for Participation

To receive a certificate of participation, participants must:

• Follow instructions to register or log in with your professional information and complete the pretest
• View the online activity in its entirety
• Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest

A certificate of participation will be available for download/printing immediately following your successful completion of the posttest and evaluation.

For questions regarding CME credit, contact the Paradigm CME Department at cme@paradigmmc.com.

There are no fees for participating in this activity.

Disclosure of Relevant Financial Relationships

In accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education, Paradigm requires that all planners, faculty, and others who are in a position to control the content of this activity disclose all financial relationships with ineligible companies during the past 24 months.

All relevant relationships are identified and mitigated according to Paradigm policy prior to individuals assuming their roles, and are disclosed prior to learners’ engagement in the activity. Paradigm is committed to providing learners with high-quality accredited continuing education that promotes improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The content of this activity was independently reviewed to ensure that it is fair and balanced, scientifically rigorous, evidence based, and aligned with the public interest. All relevant relationships have been mitigated.

April W. Armstrong, MD, MPH
Advisor: Regeneron Pharmaceuticals Inc; UCB S.A.
Consultant: Almirall, S.A.; Amgen Inc; Arcutis Biotherapeutics; ASLAN Pharmaceuticals; Beiersdorf Global; Bristol-Myers Squibb Company; Dermavant Sciences, Inc.; EPI Health, LLC; Janssen Pharmaceuticals, Inc; LEO Pharma Inc; Mindera Health; Nimbus Therapeutics; Organon; Sanofi; Sun Pharmaceutical Industries Ltd; Takeda Pharmaceutical Company Ltd; Ventyx Biosciences
Speakers Bureau: AbbVie Inc.; Amgen Inc; Bristol-Myers Squibb Company; Janssen Pharmaceuticals, Inc; Mindera Health; Organon; Sanofi; Takeda Pharmaceutical Company Ltd
Research Funding: AbbVie Inc.; ASLAN Pharmaceuticals; Bristol-Myers Squibb Company; Dermavant Sciences, Inc.; Dermira; Eli Lilly and Company; Galderma Laboratories, L.P.; InCyte; Janssen Pharmaceuticals, Inc; LEO Pharma Inc; Meiji Holdings Co., Ltd.; Nimbus Therapeutics; Novartis AG; Ortho Dermatologics; Pfizer Inc; Sanofi; UCB S.A.; Ventyx Biosciences
Other (DSMB): Boehringer Ingelheim International GmbH; Parexel 

Amit Garg, MD
Consultant: AbbVie Inc.; Aclaris Therapeutics, Inc.; AnaptysBio, Inc.; Aristea Therapeutics; Boehringer Ingelheim International GmbH; Bristol-Myers Squibb Company; Incyte; Insmed; Janssen Pharmaceuticals, Inc; Novartis AG; Pfizer Inc; Sonoma Biotherapeutics; UCB S.A.; UNION therapeutics A/S; Ventyx Biosciences; Viela Bio, Inc.
Research Funding: AbbVie Inc.; UCB S.A.
Honoraria: AbbVie Inc.; Aclaris Therapeutics, Inc.; AnaptysBio, Inc.; Aristea Therapeutics; Boehringer Ingelheim International GmbH; Bristol-Myers Squibb Company; Incyte; Insmed; Janssen Pharmaceuticals, Inc; Novartis AG; Pfizer Inc; Sonoma Biotherapeutics; UCB S.A.; UNION therapeutics A/S; Ventyx Biosciences; Viela Bio, Inc.

Mio Nakamura, MD, MS
Advisor: argenx (expired 11/23); Boehringer Ingelheim International GmbH (expired 10/23); Bristol-Myers Squibb Company (expired 11/23)
Research Funding: Amgen Inc; AnaptysBio, Inc.; argenx; Boehringer Ingelheim International GmbH; Bristol-Myers Squibb Company; Pfizer Inc; Regeneron Pharmaceuticals Inc; Takeda Pharmaceutical Industries Ltd

Paradigm Medical Communications, LLC staff members have no relevant financial relationships with ineligible companies to disclose.

GRAPPA staff reviewer has no relevant financial relationships with ineligible companies to disclose.

Independent peer reviewer has no relevant financial relationships with ineligible companies to disclose.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not approved by the FDA.

Disclaimer

This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. Reasonable efforts have been taken to present educational subject matter in a balanced, unbiased fashion, and in compliance with regulatory requirements. However, each activity participant must always use his or her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

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As an ACCME-accredited provider, Paradigm Medical Communications, LLC must ensure that its activities include a balanced view of therapeutic options. Use of generic names contributes to this impartiality. The use of trade names should not be viewed as an endorsement of specific products by Paradigm Medical Communications, LLC. 

Terms of Use and Privacy Policy
Disclaimer
The materials provided for this activity are for informational purposes only and should not be used for diagnosis or treatment of a health problem without consulting a licensed medical professional. This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. References to any entity, product, service, or source of information on this website should not be considered an endorsement, either direct or implied, by Paradigm Medical Communications, LLC. Paradigm Medical Communications, LLC accepts no liability for the content referenced in this activity.

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Collection and use of your personal information
The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing the program. Required items include first name, last name, degree, and email address. These items are necessary. Participants are also required to complete an evaluation of the CME activity. All evaluative information submitted is collected and retained, and used by Paradigm Medical Communications, LLC to continuously improve the learning experience.

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