The Role of Janus Kinase (JAK) in Autoimmune Disease


The Role of Janus Kinase (JAK) in Autoimmune Disease


Release Date: December 16, 2020
Last Reviewed: December 15, 2020
Expiration Date: December 16, 2023
Time to Complete Activity: 0.50 hour  

Faculty

April W. Armstrong, MD, MPH
Associate Dean, Clinical Research
Professor of Dermatology
Director, Clinical Research Support, Southern California CTSI
Keck School of Medicine
University of Southern California
Los Angeles, CA

Seemal R. Desai, MD, FAAD
Clinical Assistant Professor
Department of Dermatology
University of Texas Southwestern Medical Center
Dallas, TX

Gary Goldenberg, MD
Assistant Clinical Professor, Dermatology
Mount Sinai School of Medicine
New York, NY
This activity is provided by the University of Cincinnati. 
Paradigm Medical Communications, LLC is the educational partner.  
             
Disclosure of Commercial Support
This activity is supported by an educational grant from Bristol-Myers Squibb.

Target Audience
This activity has been designed to address the educational needs of dermatology clinicians. It may also be of benefit to rheumatology and primary care clinicians, as well as other healthcare providers involved with or interested in the management of patients with psoriasis.

Statement of Need
Psoriasis is a common autoimmune disorder with associated comorbidities that are more than skin deep. Patients with psoriasis are at increased risk for cardiovascular and metabolic disease, malignancies, and anxiety/depression. This activity will provide clinicians with a solid foundation for understanding the pathophysiology of psoriasis along with other autoimmune diseases, how this pathophysiology informs treatment options, and the most recent clinical trial data for current and emerging agents and management recommendations available to guide therapy selection.

Learning Objectives
Upon proper completion of this activity, participants should be better able to:

  • Describe how inhibiting the Janus kinase (JAK)/tyrosine kinase 2 (TYK2)-signal transducer and activator of transcription (STAT) pathway is effective in multiple autoimmune diseases
     

Table of Contents

  • JAK/STAT in Autoimmune Disease
    • How JAKs work
    • JAK-mediated cytokines
    • JAK/TYK2 inhibitors: Mechanisms of action
    • JAK/TYK2 inhibitors
  • Psoriasis/Psoriatic Arthritis (PsA)
    • Pathophysiology of psoriasis
    • Clinical data for JAK/TYK2 inhibitors in psoriasis
    • Pathophysiology of PsA
    • Clinical data for JAK/TYK2 inhibitors in PsA
  • Inflammatory Bowel Disease
    • Pathophysiology of inflammatory bowel disease
    • Clinical data for JAK/TYK2 inhibitors in ulcerative colitis
    • Clinical data for JAK/TYK2 inhibitors in Crohn’s disease

Physician Accreditation Statement
The University of Cincinnati is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Physician Credit Designation Statement
The University of Cincinnati designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

ABIM MOC Credit
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.50 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Canadian Continuing Professional Development (CPD) Credit: Through an agreement between the ACCME and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

PA Continuing Education
PAs may claim a maximum of 0.50 Category 1 credit for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society. 

Nurse Practitioner Continuing Education
The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.

Instructions for Participation 
To receive a CME certificate of participation, you should:

  • Follow instructions to register or log in with your professional information and complete the preactivity assessment
  • View the online activity in its entirety
  • Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest

A certificate of participation will be available for download/printing immediately following your successful completion of the posttest and evaluation.

For questions regarding CME credit, contact the Paradigm CME Department at (845) 398-5949 or cme@paradigmmc.com.

There is no fee required for participation in this activity.

Hardware/Software Requirements
This certified CME activity is designed using HTML5 video. As you navigate the video using the supplied controls, the slides will sync to the speaker.

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For desktops (Windows/Mac)
Microsoft Edge 40 or higher, Firefox 28 or higher, Safari 5.1 or higher, Google Chrome 31 or higher, Opera 21 or higher

For tablets (iPad/Android/Surface)
iOS Safari 4 or higher, Android 2.3 or higher, IE Mobile 10 or higher

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Disclosures
In accordance with ACCME requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in the activity. These relationships are described below.

April W. Armstrong, MD MPH
Consulting Fees: AbbVie Inc.; Bristol-Meyers Squibb Company; Dermavant Sciences Inc; Eli Lilly and Company; Janssen Pharmaceuticals, Inc; LEO Pharma Inc; Modernizing Medicine; Novartis; Ortho Dermatologics; Pfizer Inc; Regeneron Pharmaceuticals, Inc; Sanofi Genzyme; Sun Pharmaceutical Industries Ltd
Grant/Research Support: Abbvie Inc; Bristol-Meyers Squibb Company; Dermavant Sciences, Inc; Dermira, Inc;
Eli Lilly and Company; Janssen Pharmaceuticals, Inc; Kyowa Kirin Pharmaceutical Research, Inc; LEO Pharma Inc; Novartis; Regeneron Pharmaceuticals, Inc; Sanofi Genzyme; UCB, Inc


Seemal R. Desai, MD, FAAD
Consulting Fees: Bristol-Myers Squibb Company; Pfizer Inc
Speakers Bureau: Pfizer Inc

Gary Goldenberg, MD
Consulting Fees: AbbVie Inc.; Eli Lilly and Company; Pfizer Inc
Speakers Bureau: AbbVie Inc.; Eli Lilly and Company; Pfizer Inc


University of Cincinnati staff members and reviewers have no financial relationships to disclose.

Paradigm Medical Communications, LLC staff members have no financial relationships to disclose.

Independent peer, resident/fellow, and patient reviewers have no financial relationships to disclose.

Resolution of Conflict of Interest
The University of Cincinnati has implemented a system to resolve conflicts of interest for each CME activity to help ensure content is objective, fair and balanced, independent, and aligned with the public interest. Conflicts, if any, are resolved through one or more processes. All CME content in this activity was independently reviewed to ensure that it is free of commercial bias, scientifically rigorous, aligned with the public interest, and compliant with all regulatory guidance and the ACCME’s Standards for Commercial Support of Continuing Medical Education.

Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not approved by the FDA.


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