Release Date: February 4, 2026
Expiration Date: February 4, 2027
Time to Complete Activity: 15 minutes

Co-Chair

Daniel Schmolze, MD
Associate Clinical Professor 
Department of Pathology 
Medical Director, Digital Pathology 
City of Hope
Duarte, CA
 

Target Audience 

This activity has been designed to address the educational needs of institutional and community-based pathology clinicians and other clinicians who are involved in the management of patients with metastatic breast cancer (mBC).
 

Supporter Acknowledgment 

This activity is supported by educational grants from AstraZeneca and Daiichi Sankyo, Inc.
 

Educational Providers 

This activity is provided by Paradigm Medical Communications, LLC. (ACCME) 
 

Physician Accreditation Statement

Paradigm Medical Communications, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

 

Physician Credit Designation Statement

Paradigm Medical Communications, LLC designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
 

PA Continuing Education 

PAs may claim a maximum of 0.25 Category 1 credit for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society.
 

Nurse Practitioner Continuing Education 

The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.
 

Nursing Continuing Education

This activity is jointly provided by Global Education Group (Global) and Paradigm Medical Communications, LLC. (ANCC) 

Global Education Group is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.

This educational activity for 0.25 contact hour including 0.0 pharmacotherapeutic contact hour is provided by Global Education Group. Nurses should claim only the credit commensurate with the extent of their participation in the activity.
 

Collaborating Partners

In partnership with City of Hope, Los Angeles Society of Pathologists, and the Medical Oncology Association of Southern California.

 

Program Overview 

Join this cutting-edge CME activity designed to provide guidance for pathologists navigating the evolving landscape of human epidermal growth factor receptor 2 (HER2)-low and HER2-ultralow expression in mBC. An informative survey with detailed explanations will evaluate current approaches to HER2 testing and interpretation, and help refine assessment precision to provide medical oncology colleagues with the most up-to-date and accurate test results, which will expand treatment options for patients.
 

Learning Objectives

Upon completion of this activity, participants should be able to:

• Review updated categories of HER2 expression for breast tumors, with a focus on the categories of HER2 low and HER2 ultralow
• Apply the latest approaches to interpreting HER2 staining patterns to appropriately communicate expression levels in the pathology report
• Summarize the latest clinical trial data of antibody-drug conjugates for the treatment of HER2-low and -ultralow, metastatic and/or relapsed/refractory advanced BC

Hardware/Software Requirements

This accredited CME activity is designed using HTML5 web components. As you navigate the video using the supplied controls, the slides will sync to the speaker.
Supported Browsers (Desktop/Mobile)
Chrome 45+, Firefox 40+, Edge, Edge Chromium, Safari 8+, Opera 31+
PDF documents
This activity may contain PDF documents. Most current browsers support viewing of PDFs natively, but you may also download a free version of Adobe Acrobat Reader here: http://get.adobe.com/reader

Technical Support: If you have any technical problems or playback issues, email us at contactus@paradigmmc.com.
 

Instructions for Participation

To receive a certificate and claim credit, participants must:

• Follow instructions to register or log in with your professional information and complete the pre-activity evaluation
• View the online activity in its entirety
• Complete and submit the online evaluation. A certificate of participation will be available for download/printing immediately following your successful completion of the evaluation.
  
  For questions regarding CME credit, contact the Paradigm CME Department at cme@paradigmmc.com.
  
  There are no fees for participating in this activity.
   

Disclosure of Relevant Financial Relationships

In accordance with the Accreditation Council for Continuing Medical Education’s (ACCME) Standards for Integrity and Independence in Accredited Continuing Education, Paradigm requires that all planners, faculty, and others who are in a position to control the content of this activity disclose all financial relationships with ineligible companies during the past 24 months.

All relevant relationships are identified and mitigated according to Paradigm and Global policy prior to individuals assuming their roles and are disclosed prior to learners’ engagement in the activity. Paradigm is committed to providing learners with high-quality accredited continuing education that promotes improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The content of this activity was independently reviewed to ensure that it is fair and balanced, scientifically rigorous, evidence based, and aligned with the public interest. All relevant relationships have been mitigated.

Daniel Schmolze, MD 
Has no relevant financial relationships with ineligible companies to disclose.

Staff 
Paradigm Medical Communications, LLC, City of Hope, Global Education Group, Los Angeles Society of Pathologists, and the Medical Oncology Association of Southern California staff members have no relevant financial relationships with ineligible companies to disclose.

Independent peer reviewer has no relevant financial relationships with ineligible companies to disclose.
 

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not approved by the FDA.
 

Disclaimer

This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC and Global. Reasonable efforts have been taken to present educational subject matter in a balanced, unbiased fashion, and in compliance with regulatory requirements. However, each activity participant must always use his or her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

If included, signed statements of informed consent granting permission for publication have been obtained for all photographs and videos in which an individual can be identified.

As an ACCME-accredited provider, Paradigm Medical Communications, LLC must ensure that its activities include a balanced view of therapeutic options. Use of generic names contributes to this impartiality. The use of trade names should not be viewed as an endorsement of specific products by Paradigm Medical Communications, LLC.

Terms of Use and Privacy Policy
Disclaimer
The materials provided for this activity are for informational purposes only and should not be used for diagnosis or treatment of a health problem without consulting a licensed medical professional. This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. References to any entity, product, service, or source of information on this website should not be considered an endorsement, either direct or implied, by Paradigm Medical Communications, LLC. Paradigm Medical Communications, LLC accepts no liability for the content referenced in this activity.

Privacy policy
Paradigm Medical Communications, LLC or hosted contracted partner is committed to protecting the privacy of those who participate in the activities located at www.paradigmmc.com (herein referred to as “website”). The information below describes the security of the website for safeguarding personal information and the rationale for collection and use of personal information.

Security/safeguarding personal information
This website has physical and procedural safeguards in place to prevent unauthorized access to personal information used to access this website.

Collection and use of your personal information
The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing the program and may be used to track registration and participation. Required items include first name, last name, degree, and email address. These items are necessary. Participants are also required to complete an evaluation of the CME activity. All evaluative information submitted is collected and retained, and used by Paradigm Medical Communications, LLC to continuously improve the learning experience.

Paradigm Medical Communications, LLC does not otherwise transfer, sell, or share personal information with outside parties. Paradigm Medical Communications, LLC will not otherwise disclose personal information unless required to in a legal process. Paradigm Medical Communications, LLC staff members review individual test results to the extent necessary to record and track participants’ credits.

Contact Us

If you have any questions or comments, please email us at contactus@paradigmmc.com.

For information about the accreditation (ANCC credit) of this program, please contact Global at 303-395-1782 or cme@globaleducationgroup.com.

© 2026 Paradigm Medical Communications, LLC except where noted. Content may not be reproduced in whole or part without the express written permission of Paradigm Medical Communications, LLC.