Treatment Selection for Patients With NSCLC With High PD-L1 Expression

Treatment Selection for Patients With NSCLC With High PD-L1 Expression

Release Date: February 4, 2021
Last Reviewed: February 1, 2021
Expiration Date: February 4, 2022
Time to Complete Activity:  0.50 hour

*This activity expired for credit on February 4, 2022 and is no longer available for credit


Karen Reckamp, MD, MS
Director, Division of Medical Oncology 
Associate Director, Clinical Research
Cedars-Sinai Cancer
Los Angeles, CA

Matthew D. Hellmann, MD
Medical Oncologist
Memorial Sloan Kettering Cancer Center
New York, NY

This activity is provided by Paradigm Medical Communications, LLC.   

Disclosure of Commercial Support
This activity is supported by an educational grant from Bristol-Myers Squibb Company and Merck & Co, Inc.

Target Audience
This activity has been designed to address the educational needs of medical oncologists. It may also be of benefit to other healthcare professionals (HCPs) who manage patients with non-small cell lung cancer (NSCLC).

Statement of Need
The first-line treatment of advanced NSCLC without actionable mutations has undergone a dramatic change over the last 5 years, with the standard of care changing from chemotherapy to immune checkpoint inhibitor (ICI) monotherapy for select patients, to a variety of ICI-based combination regimens in addition to monotherapy. In addition, several more ICI-based regimens are currently under US Food and Drug Administration (FDA) review and are expected to be added to the armamentarium in the near future. Although these multiple first-line regimens provide oncology clinicians and their patients with options to select from, this also creates a major challenge: Remaining up to date on the latest clinical trial data for existing and emerging ICI-based regimens, as well as applying these changes to improve treatment selection.

Learning Objectives
Upon completion of this activity, participants should be able to:
  • Evaluate the latest clinical trial data on immunotherapy-based combination regimens for the first-line treatment of NSCLC.
  • Select evidence-based first-line therapy for patients with advanced NSCLC, while considering patient- and treatment-related characteristics.


  • Introduction to NSCLC treatment
  • Current and pending FDA approvals for the first-line treatment of NSCLC
  • Case: Patient with newly diagnosed NSCLC with high PD-L1 expression
    • Update on clinical trial data
    • Treatment selection
    • Management of irAEs
  • Conclusion and faculty panel discussion
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  • View the online activity in its entirety
  • Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest
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In accordance with ACCME requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in the activity. These relationships are described below. Any potential conflicts of interest have been resolved.

Matthew D. Hellmann, MD
Royalty: AstraZeneca; Bristol-Myers Squibb Company; Eli Lilly and Company
Consulting Fees: Achilles; Arcus; AstraZeneca; Blueprint Medicines Corporation; Bristol-Myers Squibb Company; Genentech, Inc; Immuna; Merck & Co, Inc; Mirati; Nektar; Shattuck Labs, Inc; Syndax 
Grant/Research Support: Bristol-Myers Squibb Company
Stock Shareholder: Arcus; Immunai; Shattuck Labs, Inc

Karen Reckamp, MD, MS
Consulting Fees: Amgen Inc; AstraZeneca; Blueprint Medicines Corporation; Calithera Biosciences, Inc; Daiichi Sankyo, Inc; Eli Lilly and Company; Euclises Pharmaceuticals, Inc; Genentech, Inc.; Guardant Health Janssen Pharmaceuticals, Inc; KGA; Merck & Co, Inc; Precision Health; Takeda Pharmaceutical Company Ltd; Tesaro
Grant/Research Support: AbbVie Inc; ACEA Biosciences; Adaptimmune; Boehringer Ingelheim Pharmaceuticals, Inc; Bristol-Myers Squibb Company; Cedars Sinai; Calithera Biosciences, Inc.; Genentech, Inc.; GlaxoSmithKline; Guardant Health; Janssen Pharmaceuticals, Inc; Loxo Oncology; Molecular Partners; Seattle Genetics; Spectrum Pharmaceutical, Inc.; Takeda Pharmaceutical Company Ltd; Xcovery; Zenopharm

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