Release Date:August 22, 2024 
Expiration Date: August 22, 2025
Time to Complete Activity: 0.75 hour

Faculty

Jason J. Luke, MD, FACP
Associate Director for Clinical Research
Director, Immunotherapy and Drug Development Center
Associate Professor of Medicine
UPMC Hillman Cancer Center and University of Pittsburgh
Pittsburgh, PA

Sapna P. Patel, BA, MD
Dr William Robinson Endowed Chair in Cancer Research
Director, Cutaneous Oncology Program
Professor of Medicine and Ophthalmology
University of Colorado Cancer Center
Aurora, CO
 

Target Audience 

This activity has been designed to address the educational needs of medical oncologists and dermatologists. It may also be of benefit to oncology nurse practitioners, PAs, and other healthcare professionals who are interested in the management of patients with melanoma.
 

Educational Provider 

This activity is provided by Paradigm Medical Communications, LLC.  
 

Supporter Acknowledgment 

This activity is supported by an educational grant from Merck Sharp & Dohme LLC.
 

Program Overview 

The field of immunotherapy for melanoma is rapidly evolving. Recent developments, such as key data published or presented, have provided insights into the ever-expanding role of immune checkpoint inhibitors (ICIs) in the management of both early and advanced disease. Join this engaging case-based review of current treatments and see where emerging treatments are heading.
 

Learning Objectives

Upon completion of this activity, participants should be able to:

• Review ongoing clinical trials and recent clinical trial data, including the most recent efficacy and safety data on dual LAG-3/programmed cell death protein 1 combination regimens in melanoma
• Discuss recent clinical data supporting the use of ICIs in melanoma, including resectable and unresectable disease
• Identify the optimal sequence of systemic therapies for patients with unresectable disease
• Discuss a response-directed approach to the treatment of resectable disease

Physician Accreditation Statement

Paradigm Medical Communications, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
 

Physician Credit Designation Statement

Paradigm Medical Communications, LLC designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
 

PA Continuing Education 

PAs may claim a maximum of 0.75 Category 1 credit for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society.
 

Nurse Practitioner Continuing Education 

The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.
 

Hardware/Software Requirements

This accredited CME activity is designed using HTML5 web components. As you navigate the video using the supplied controls, the slides will sync to the speaker.

Supported Browsers (Desktop/Mobile)
Chrome 45+, Firefox 40+, Edge, Edge Chromium, Safari 8+, Opera 31+

PDF documents
This activity may contain PDF documents. Most current browsers support viewing of PDFs natively, but you may also download a free version of Adobe Acrobat Reader here: http://get.adobe.com/reader

Technical Support
If you have any technical problems or playback issues, email us at contactus@paradigmmc.com.

Instructions for Participation

To receive a certificate of participation, participants must:

• Follow instructions to register or log in with your professional information and complete the pretest
• View the online activity in its entirety
• Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest

A certificate of participation will be available for download/printing immediately following your successful completion of the posttest and evaluation.

For questions regarding CME credit, contact the Paradigm CME Department at cme@paradigmmc.com.

There are no fees for participating in this activity.

Disclosure of Relevant Financial Relationships

In accordance with the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education, Paradigm requires that all planners, faculty, and others who are in a position to control the content of this activity disclose all financial relationships with ineligible companies during the past 24 months.

All relevant relationships are identified and mitigated according to Paradigm policy prior to individuals assuming their roles and are disclosed prior to learners’ engagement in the activity. Paradigm is committed to providing learners with high-quality accredited continuing education that promotes improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The content of this activity was independently reviewed to ensure that it is fair and balanced, scientifically rigorous, evidence based, and aligned with the public interest. All relevant relationships have been mitigated.

Jason J. Luke, MD, FACP
Consultant: AbbVie Inc.; Agenus Inc.; Alnylam Pharmaceuticals, Inc.; AskGene Pharma Inc.; AstraZeneca; Atomwise; Bayer Corporation; Bristol-Myers Squibb Company; Castle Biosciences; Checkmate Therapeutics; Codiak Biosciences; Crown Bioscience; Cugene, Inc.; Curadev; Day One Biopharmaceuticals, Inc.; Eisai Inc.; EMD Serono; Endeavor BioMedicines; Flame Biosciences; G1 Therapeutics; Genentech, Inc.; Geneos Therapeutics, Inc.; Gilead Sciences, Inc.; Glenmark Pharmaceuticals; HotSpot Therapeutics; Ikena Oncology; Inzen Therapeutics, Inc.; Immatics N.V.; Immunocore Holdings, plc; InCyte; Instil Bio; IO Biotech; Janssen Pharmaceuticals, Inc;  Kadmon Corporation; KoBioLabs; Krystal Biotech, Inc.; KSQ Therapeutics, Inc.; LegoChem Biosciences; Lyvgen Biopharma; MacroGenics, Inc.; Merck & Co, Inc; Mersana Therapeutics; Nektar Therapeutics; Novartis AG; Partner Therapeutics; Pfizer Inc; Pioneering Medicines; PsiOxus Therapeutics; Regeneron Pharmaceuticals Inc; Replimune Group Inc.; Ribon Therapeutics; Roivant Sciences; Servier Pharmaceuticals; Stingthera, Inc.; STORM Therapeutics LTD; Sumitomo Corporation; Synlogic; Synthekine; Teva Pharmaceutical Industries Ltd
Research Funding: AbbVie Inc.; Astellas Pharma US, Inc; AstraZeneca; Bristol-Myers Squibb Company; Corvus Pharmaceuticals; Day One Biopharmaceuticals, Inc.; EMD Serono; F-star Therapeutics Inc.; Genmab A/S; HotSpot Therapeutics; Ikena Oncology; Immatics N.V.; Imugene Ltd; InCyte; Janux Therapeutics; Kadmon Corporation; KAHR medical; MacroGenics, Inc; Merck & Co, Inc; Moderna, Inc.; Nektar Therapeutics; NextCure, Inc.; Novartis AG; Numab Therapeutics AG; Palleon Pharmaceuticals; Pfizer Inc; Replimune Group Inc.; Rubius Therapeutics; Scholar Rock, Inc.; Servier Pharmaceuticals; Synlogic; Takeda Pharmaceutical Company Ltd; Tizona Therapeutics, Inc.; Trishula Therapeutics, Inc.; Tsan Therapeutics; Werewolf Therapeutics; Xencor (all funds paid to institution)
Patent Beneficiary: US-11638728 (Microbiome Biomarkers for Anti-PD-1/PD-L1 Responsiveness: Diagnostic, Prognostic and Therapeutic Uses Thereof)
Other (Scientific Advisory Board With Stocks): Actym Therapeutics, Inc.; Alphamab Oncology; Arch Oncology; Duke Street Bio Ltd; Elpiscience; Kanaph Therapeutics; NeoTX; Onc.AI; OncoNano; physIQ; Pyxis Oncology; Saros Therapeutics; STipe Therapeutics; Tempest Therapeutics, Inc.
Other (Scientific Advisory Board): 7 Hills Pharma Inc.; Affivant Sciences; BioCytics Inc.; Bright Peak Therapeutics; Exo Therapeutics, Inc.; F-star Therapeutics Inc.; Inzen Therapeutics, Inc.; RefleXion; Xilio Therapeutics
Other (DSMB): AbbVie Inc.; Agenus Inc.; Immutep Ltd; Shionogi Inc.

Sapna P. Patel, BA, MD
Advisor: Bristol-Myers Squibb Company; Cardinal Health; Castle Biosciences, Inc.; Merck & Co., Inc.; Novartis AG; Pfizer Inc; Replimune Group Inc.; TriSalus Life Sciences, Inc.
Consultant: IDEAYA Biosciences
Speakers Bureau: Bristol-Myers Squibb Company; Merck & Co., Inc.

Paradigm Medical Communications, LLC staff members have no relevant financial relationships with ineligible companies to disclose.

Independent peer reviewer has no relevant financial relationships with ineligible companies to disclose.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not approved by the FDA.

Disclaimer

This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. Reasonable efforts have been taken to present educational subject matter in a balanced, unbiased fashion, and in compliance with regulatory requirements. However, each activity participant must always use his or her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

If included, signed statements of informed consent granting permission for publication have been obtained for all photographs and videos in which an individual can be identified.

As an ACCME-accredited provider, Paradigm Medical Communications, LLC must ensure that its activities include a balanced view of therapeutic options. Use of generic names contributes to this impartiality. The use of trade names should not be viewed as an endorsement of specific products by Paradigm Medical Communications, LLC.

Terms of Use and Privacy Policy
Disclaimer
The materials provided for this activity are for informational purposes only and should not be used for diagnosis or treatment of a health problem without consulting a licensed medical professional. This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. References to any entity, product, service, or source of information on this website should not be considered an endorsement, either direct or implied, by Paradigm Medical Communications, LLC. Paradigm Medical Communications, LLC accepts no liability for the content referenced in this activity.

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Security/safeguarding personal information
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Collection and use of your personal information
The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing the program. Required items include first name, last name, degree, and email address. These items are necessary. Participants are also required to complete an evaluation of the CME activity. All evaluative information submitted is collected and retained, and used by Paradigm Medical Communications, LLC to continuously improve the learning experience.

Paradigm Medical Communications, LLC does not transfer, sell, or share personal information with outside parties. Paradigm Medical Communications, LLC will not otherwise disclose personal information unless required to in a legal process. Paradigm Medical Communications, LLC staff members review individual test results to the extent necessary to record and track participants’ credits.

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