Targeting Inflammatory and Fibrotic Pathways in SSc-ILD
Release Date: July 9, 2021
Last Reviewed: July 2, 2021
Expiration Date: July 9, 2022
Time to Complete Activity: 1.25 hours
Fernando Jose Martinez, MD, MS
Bruce Webster Professor of Internal Medicine
Chief, Division of Pulmonary and Critical Care Medicine
Weill Cornell Medicine
New York, NY
Elizabeth R. Volkmann, MD, MS
Assistant Professor of Medicine
Director, UCLA Scleroderma Program
Co-Director, UCLA CTD-ILD Program
Division of Rheumatology
Department of Medicine
University of California, Los Angeles
David Geffen School of Medicine
Los Angeles, CA
This activity is provided by Paradigm Medical Communications, LLC.
In collaboration with the Pulmonary Fibrosis Foundation.
Disclosure of Commercial Support
This activity is supported by an educational grant from Genentech, a member of the Roche Group.
This activity has been designed to address the educational needs of academic and community-based pulmonologists and rheumatologists. It may also benefit pathologists, radiologists, dermatologists, primary care physicians, nurse practitioners, PAs, pharmacists, nurses, residents, fellows, and other healthcare professionals involved in the care of patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD).
Statement of Need
Scleroderma or systemic sclerosis (SSc) is a rare autoimmune disorder characterized by fibrosis in the skin and internal organs, including the lungs, that results in increased morbidity and mortality for patients. SSc-ILD occurs in the majority of patients. Due to the rarity of the disease and the heterogeneity of symptoms, patients often experience diagnostic delay until referral to an appropriate specialist, thus delaying the opportunity for early treatment. For patients with risk factors for severe interstitial lung disease (ILD), rapid progression often occurs within the first 5 years from diagnosis. There is no curative treatment for SSc, but immunosuppressive agents and now antifibrotics are available to delay the progression of SSc-ILD. Patients with SSc need appropriate screening and monitoring for ILD. Patients presenting with ILD need appropriate screening for SSc, so that appropriate therapy can be initiated. Data are emerging for additional anti-inflammatory therapies that impact fibrosis, including tocilizumab and rituximab, as well as pirfenidone, an antifibrotic with efficacy in other forms of ILD. In this webinar diagnosis of SSc-ILD is reviewed for patients presenting with SSc and those presenting with ILD. Data for immunotherapies and antifibrotics are discussed, along with selecting therapy based on individual patient characteristics and risk factors for disease progression.
Upon completion of this activity, participants should be able to:
- Outline risk factors for progressive SSc-ILD
- Assess recommended monitoring for patients with scleroderma and SSc-ILD
- Select appropriate, evidence-based therapy for patients who have SSc-ILD
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Fernando Jose Martinez, MD, MS
Consulting Fees: Boehringer Ingelheim Pharmaceuticals, Inc; Bristol-Myers Squibb Company; DevPro Biopharma LLC; Sanofi-aventis U.S. LLC; Shionogi Inc.; United Therapeutics Corporation; Veracyte, Inc.
Grant/Research Support: Afferent Pharmaceuticals/Merck & Co, Inc; Bayer Corporation; Biogen-Idec; Respivant Sciences Company; Roche
Elizabeth R. Volkmann, MD, MS
Consulting Fees: Boehringer Ingelheim Pharmaceuticals, Inc
Grant/Research Support: Bristol Myers Squibb Company; Corbus Pharmaceuticals Holdings, Inc; Forbius; Kadmon Holdings, Inc
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Independent peer reviewer has no financial relationships to disclose.
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