Release Date: June 30, 2026
Expiration Date: June 30, 2027
Time to Complete Activity: 1.0 hour

Faculty 

Theodore Leng, MD, MS 
Professor of Ophthalmology
Director of Clinical and Translational Research
Byers Eye Institute at Stanford
Stanford University School of Medicine
Palo Alto, CA
Medical Informatics Director, Ambulatory Services
Stanford Health Care
Stanford, CA
 
Carl D. Regillo, MD, FACS 
Director, Retina Service
Wills Eye Hospital
Partner, Mid Atlantic Retina
Professor of Ophthalmology
Thomas Jefferson University
Philadelphia, PA
 

Target Audience 

This activity has been designed to address the educational needs of retina specialists and other ophthalmologists.
 

Educational Provider 

This activity is provided by Paradigm Medical Communications, LLC. 

 

Supporter Acknowledgment 

This activity is supported by an educational grant from Genentech, a member of the Roche Group.
 

Program Overview 

Do clinical trial results predict real-world outcomes for patients with diabetic macular edema or neovascular age-related macular degeneration who receive second-generation retinal therapies? Real-world factors to consider include more diverse patients, less-controlled practice conditions, and variability in treatment patterns and durability. This interactive, match game–style CME activity compares second generation retinal therapies across efficacy, safety, and durability, helping ophthalmologists reconcile clinical trial data with real-world findings to optimize outcomes in routine practice where formal guidance is limited.
 

Learning Objectives

Upon completion of this activity, participants should be able to:

• Evaluate the outcomes of second-generation retinal therapies reported in the real world versus those reported in clinical trials
• Optimize the treatment of patients with neovascular retinal disease with consideration of data from both clinical trials and the real world

Physician Accreditation Statement

Paradigm Medical Communications, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

 

Physician Credit Designation Statement

Paradigm Medical Communications, LLC designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
 

PA Continuing Education 

PAs may claim a maximum of 1.0 Category 1 credit for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society.
 

Nurse Practitioner Continuing Education 

The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.
 

Hardware/Software Requirements

This accredited CME activity is designed using HTML5 web components. As you navigate the video using the supplied controls, the slides will sync to the speaker.
Supported Browsers (Desktop/Mobile)
Chrome 45+, Firefox 40+, Edge, Edge Chromium, Safari 8+, Opera 31+
PDF documents
This activity may contain PDF documents. Most current browsers support viewing of PDFs natively, but you may also download a free version of Adobe Acrobat Reader here: http://get.adobe.com/reader

Technical Support: If you have any technical problems or playback issues, email us at contactus@paradigmmc.com.
 

Instructions for Participation

To receive a certificate and claim credit, participants must:

• Follow instructions to register or log in with your professional information and complete the pretest
• View the online activity in its entirety
• Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest

A certificate of participation will be available for download/printing immediately following your successful completion of the posttest and evaluation.

For questions regarding CME credit, contact the Paradigm CME Department at cme@paradigmmc.com.

There are no fees for participating in this activity.
 

Disclosure of Relevant Financial Relationships

In accordance with the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education, Paradigm requires that all planners, faculty, and others who are in a position to control the content of this activity disclose all financial relationships with ineligible companies during the past 24 months.

All relevant relationships are identified and mitigated according to Paradigm policy prior to individuals assuming their roles and are disclosed prior to learners’ engagement in the activity. Paradigm is committed to providing learners with high-quality accredited continuing education that promotes improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The content of this activity was independently reviewed to ensure that it is fair and balanced, scientifically rigorous, evidence based, and aligned with the public interest. All relevant relationships have been mitigated.

Theodore Leng, MD, MS 
Consultant: 4D Molecular Therapeutics (expired 12/2025); Apellis Pharmaceuticals, Inc (expired 10/2025); Astellas Pharma US, Inc (expired 7/2025); Boehringer Ingelheim International GmbH; Carrot; Digital Diagnostics Inc. (expired 6/2025); F. Hoffmann-La Roche AG (expired 10/2024); Regeneron Pharmaceuticals Inc; Toku Eyes; Topcon Corporation
Research Funding: Astellas Pharma US, Inc; Luxa Biotechnology

Carl D. Regillo, MD, FACS 
Consultant: 4D Molecular Therapeutics; Adverum Biotechnologies, Inc; Alcon; Allergan, Inc.; Amgen Inc; Annexon, Inc; Apellis Pharmaceuticals, Inc; Ashvattha Therapeutics; Aviceda Therapeutics; Bausch & Lomb; BioCryst Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH; Breye Therapeutics ApS; Chengdu Kanghong Pharmaceutical Group Co, LTD; Clearside Biomedical; Cognition Therapeutics; Endogena Therapeutics Inc; EyePoint Pharmaceuticals, Inc; Genentech, Inc; IVERIC bio, Inc; Janssen Pharmaceuticals, Inc; jCyte, Inc.; Kodiak Sciences Inc; Kyoto Drug Discovery & Development Co., Ltd.; Lineage Cell Therapeutics, Inc; Merck & Co, Inc; Nanoscope Therapeutics, Inc; Neurotech Pharmaceuticals, Inc; NGM Biopharmaceuticals; Novartis AG; Novelty Nobility Inc; Ocugen, Inc.; OcuTerra Therapeutics; ONL Therapeutics, Inc.; Opus Genetics, Inc.; Opthea; Outlook Therapeutics, Inc; Ray Therapeutics; REGENXBIO Inc; Sanofi; Stealth BioTherapeutics Inc; Thea Pharma Inc; ZEISS International; ZipBio
Research Funding: 4D Molecular Therapeutics; Adverum Biotechnologies, Inc; agtc; Alcon; Allergan, Inc.; Annexon, Inc; Apellis Pharmaceuticals, Inc; Astellas Pharma US, Inc; EyeBio; EyePoint Pharmaceuticals, Inc; Genentech, Inc; Janssen Pharmaceuticals, Inc; Kodiak Sciences Inc; Lineage Cell Therapeutics, Inc; NGM Biopharmaceuticals; Novartis AG; Ocugen, Inc.; OcuTerra Therapeutics; Opthea; Regeneron Pharmaceuticals Inc; REGENXBIO Inc; Stealth BioTherapeutics Inc
Stocks: Aviceda Therapeutics; Ocugen, Inc.; ZipBio

Paradigm Medical Communications, LLC staff members have no relevant financial relationships with ineligible companies to disclose.

Peer Reviewer
Advisor: AbbVie Inc (expired 4/2026)
 

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not approved by the FDA.
 

Disclaimer

This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. Reasonable efforts have been taken to present educational subject matter in a balanced, unbiased fashion, and in compliance with regulatory requirements. However, each activity participant must always use his or her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

If included, signed statements of informed consent granting permission for publication have been obtained for all photographs and videos in which an individual can be identified.

As an ACCME-accredited provider, Paradigm Medical Communications, LLC must ensure that its activities include a balanced view of therapeutic options. Use of generic names contributes to this impartiality. The use of trade names should not be viewed as an endorsement of specific products by Paradigm Medical Communications, LLC.

Terms of Use and Privacy Policy
Disclaimer
The materials provided for this activity are for informational purposes only and should not be used for diagnosis or treatment of a health problem without consulting a licensed medical professional. This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. References to any entity, product, service, or source of information on this website should not be considered an endorsement, either direct or implied, by Paradigm Medical Communications, LLC. Paradigm Medical Communications, LLC accepts no liability for the content referenced in this activity.

Privacy policy
Paradigm Medical Communications, LLC or hosted contracted partner is committed to protecting the privacy of those who participate in the activities located at www.paradigmmc.com (herein referred to as “website”). The information below describes the security of the website for safeguarding personal information and the rationale for collection and use of personal information.

Security/safeguarding personal information
This website has physical and procedural safeguards in place to prevent unauthorized access to personal information used to access this website.

Collection and use of your personal information
The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing the program and may be used to track registration and participation. Required items include first name, last name, degree, and email address. These items are necessary. Participants are also required to complete an evaluation of the CME activity. All evaluative information submitted is collected and retained, and used by Paradigm Medical Communications, LLC to continuously improve the learning experience.

Paradigm Medical Communications, LLC does not otherwise transfer, sell, or share personal information with outside parties. Paradigm Medical Communications, LLC will not otherwise disclose personal information unless required to in a legal process. Paradigm Medical Communications, LLC staff members review individual test results to the extent necessary to record and track participants’ credits.
 

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