Advances in Immunotherapy for Advanced Melanoma: Integrating Intralesional and Anti-PD-1 Immunotherapies into Current Practice


Release Date: May 22, 2015
Last Reviewed: May 8, 2015
Expiration Date: May 22, 2016
Time to Complete Activity:  2.0 hours

*This activity expired for credit on May 22, 2016 and is no longer available for credit​

Faculty
Robert H.I. Andtbacka, MD, CM (Chair)
Associate Professor
Department of Surgery, Division of General Surgery
University of Utah
Huntsman Cancer Institute
Salt Lake City, UT

Sanjiv Agarwala, MD
Chief of Medical Oncology and Hematology
St Luke’s University Hospital & Health Network
Bethlehem, PA
Professor of Medicine
Temple University School of Medicine
Philadelphia, PA

Kenneth F. Grossmann, MD, PhD
Assistant Professor
Division of Oncology
Department of Medicine
University of Utah
Medical Oncologist and Investigator
Melanoma and Cutaneous Oncology Program
Huntsman Cancer Institute
Salt Lake City, UT

Merrick I. Ross, MD
Professor of Surgery
Chief, Melanoma Section
Charles M. McBride Distinguished Professor
Department of Surgical Oncology
University of Texas MD Anderson Cancer Center
Houston, TX
This activity is provided by Paradigm Medical Communications, LLC.

Target Audience
This activity has been designed to address the educational needs of surgical oncologists. This activity may also be of benefit to other healthcare providers who manage patients with melanoma.

Learning Objectives
Upon proper completion of this activity, participants should be better able to:

  • Formulate melanoma treatment plans that integrate PD-1 inhibitors and intralesional immunotherapies with other established therapies for appropriate patients.
  • Describe the mechanisms of action and tumor responses associated with PD-1 inhibitors and intralesional immunotherapies.
  • Differentiate between the response to immunotherapies and response to cytotoxic and targeted therapies in patients with melanoma.

Accreditation Statement
Paradigm Medical Communications, LLC is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designation Statement
Paradigm Medical Communications, LLC designates this enduring material for a maximum of 2.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure of Commercial Support
This activity is supported by an educational donation provided by Amgen and an educational grant from Provectus Biopharmaceuticals, Inc.

Instructions for Participation
To receive a CME certificate of participation, you should:

  • Follow instructions to register or log in with your professional information and complete the pre-activity assessment.
  • View the online activity in its entirety.
  • Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest.

A certificate of participation will be available for download/printing immediately following your successful completion of the posttest and evaluation.

There is no fee required for participation in this activity.

Hardware/Software Requirements
This certified CME activity is designed using HTML5 video. As you navigate the video using the supplied controls, the slides will sync to the speaker.

Supported Browsers:
For Desktops (Windows/Mac)
Internet Explorer 9 or higher, Firefox 28 or higher, Safari 5.1 or higher, Google Chrome 31 or higher, Opera 21 or higher

For Tablets (iPad/Android/Surface)

iOS Safari 4 or higher, Android 2.3 or higher, IE Mobile 10 or higher

Technical Support: If you have any technical problems or playback issues email us at contactus@paradigmmc.com.

Disclosures
In accordance with Accreditation Council for Continuing Medical Education requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in the activity. These relationships are described below.

Robert H.I. Andtbacka, MD, CM
Retained Consultant: Amgen Inc., Provectus

Sanjiv Agarwala, MD
Retained Consultant: Provectus

Kenneth F. Grossmann, MD, PhD
No financial relationships to disclose

Merrick I. Ross, MD
Retained Consultant: Amgen Inc; GlaxoSmithKline; Merck & Co, Inc
Speakers Bureau: Amgen Inc; GlaxoSmithKline; Merck & Co, Inc

Paradigm Medical Communications, LLC staff members have no financial relationships to disclose.

Peer reviewer Sancy Leachman, MD has the following financial relationships to disclose:
Medical Scientific Advisory Board:Myraid Genetics Laboratory

Resolution of Conflict of Interest
Paradigm Medical Communications, LLC has implemented a system to resolve conflicts of interest for each CME activity to help ensure content objectivity, independence, fair balance, and that the content is aligned with the interest of the public. Conflicts, if any, are resolved through one or more processes. All CME content in this activity was independently reviewed to ensure that it is free of commercial bias, scientifically rigorous, aligned with the public interest, and compliant with all regulatory guidance and the ACCME’s Standards for Commercial Support of Continuing Medical Education.

Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA.

Disclaimer
This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. Reasonable efforts have been taken to present educational subject matter in a balanced, unbiased fashion, and in compliance with regulatory requirements. However, each activity participant must always use his or her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

If included, signed statements of informed consent granting permission for publication have been obtained for all photographs and videos in which an individual can be identified.

As an ACCME-accredited provider, Paradigm Medical Communications, LLC activities must include a balanced view of therapeutic options. Use of generic names contributes to this impartiality.The use of trade names should not be viewed as an endorsement of specific products by Paradigm Medical Communications, LLC.

Terms of Use and Privacy Policy
Disclaimer
The materials provided for this activity are for informational purposes only, and should not be used for diagnosis or treatment of a health problem without consulting a licensed medical professional. Any views or opinions presented are solely those of the Faculty, and do not necessarily represent those of Paradigm Medical Communications, LLC. References to any entity, product, service, or source of information on this website should not be considered an endorsement, either direct or implied, by Paradigm Medical Communications, LLC. Paradigm Medical Communications, LLC accepts no liability for the content referenced in this activity.

Privacy policy
Paradigm Medical Communications, LLC is committed to protecting the privacy of those who participate in the activities (herein referred to as "website") located at www.paradigmmc.com. The information below describes the security of the website for safeguarding personal information and the rationale for collection and use of personal information.

Security/safeguarding personal information
This website has physical and procedural safeguards in place to prevent unauthorized access to personal information used to access this website.

Collection and use of your personal information
The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing the program. Required items include first name, last name, degree, and email address. These items are necessary. Participants are also required to complete an evaluation of the CME activity. All evaluative information submitted is collected and retained, and used by Paradigm Medical Communications, LLC to continuously improve the learning experience.

Paradigm Medical Communications, LLC does not transfer, sell, or share personal information with outside parties. Paradigm Medical Communications, LLC will not otherwise disclose personal information unless required to in a legal process. Paradigm Medical Communications, LLC staff members review individual test results to the extent necessary to record and track participants’ credits.

Contact Us
If you have any questions or comments, please email us at contactus@paradigmmc.com.

© 2015 Paradigm Medical Communications, LLC, except where noted. Content may not be reproduced in whole or part without the express written permission of Paradigm Medical Communications, LLC.